Overview

  • Product name

    Recombinant Human UBXN6/UBXD1 protein
  • Protein length

    Full length protein

Description

  • Nature

    Recombinant
  • Source

    Wheat germ
  • Amino Acid Sequence
    • Species

      Human
    • Sequence

      MKKFFQEFKADIKFKSAGPGQKLKESVGEKAHKEKPNQPAPRPPRQGPTN EAQMAAAAALARLEQKQSRAWGPTSQDTIRNQVRKELQAEATVSGSPEAP GTNVVSEPREEGSAHLAVPGVYFTCPLTGATLRKDQRDACIKEAILLHFS TDPVAASIMKIYTFNKDQDRVKLGVDTIAKYLDNIHLHPEEEKYRKIKLQ NKVFQERINCLEGTHEFFEAIGFQKVLLPAQDQEDPEEFYVLSETTLAQP QSLERHKEQLLAAEPVRAKLDRQRRVFQPSPLASQFELPGDFFNLTAEEI KREQRLRSEAVERLSVLRTKAMREKEEQRGLRKYNYTLLRVRLPDGCLLQ GTFYARERLGAVYGFVREALQSDWLPFELLASGGQKLSEDENLALNECGL VPSALLTFSWDMAVLEDIKAAGAEPDSILKPELLSAIEKLL
    • Amino acids

      1 to 441
    • Tags

      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab164274 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 mg/ml.

     This product was previously labelled as UBXN6

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • UBX domain containing 1
    • UBX domain containing 2
    • UBX domain containing protein 1
    • UBX domain containing protein 6
    • UBX domain protein 6
    • UBX domain-containing protein 1
    • UBX domain-containing protein 6
    • UBXD1
    • UBXDC2
    • Ubxn6
    • UBXN6_HUMAN
    see all
  • Function

    Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. MDM2 stabilization leads to MDM2-dependent TP53 degradation.
  • Tissue specificity

    Enhanced expression in testis.
  • Sequence similarities

    Contains 1 PUB (PUG) domain.
    Contains 1 UBX domain.
  • Domain

    The UBX domain lacks key residues critical for VCP binding.
  • Cellular localization

    Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Localizes at the centrosome both in interphase and during mitosis.
  • Information by UniProt

Images

  • ab164274 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab164274 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab164274.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up