Description

  • Product name

    Recombinant Human ULBP1 protein (His tag)
    See all ULBP1 proteins and peptides
  • Purity

    > 90 % SDS-PAGE.
    Purified by using conventional chromatography techniques.
  • Endotoxin level

    < 1.000 Eu/µg
  • Expression system

    Baculovirus infected insect cells
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      ADLGWVDTHC LCYDFIITPK SRPEPQWCEV QGLVDERPFL HYDCVNHKAK AFASLGKKVN VTKTWEEQTE TLRDVVDFLK GQLLDIQVEN LIPIEPLTLQ ARMSCEHEAH GHGRGSWQFL FNGQKFLLFD SNNRKWTALH PGAKKMTEKW EKNRDVTMFF QKISLGDCKM WLEEFLMYWE QMLDPTKPPS LAPGHHHHHH
    • Predicted molecular weight

      23 kDa including tags
    • Amino acids

      26 to 216
    • Tags

      His tag C-Terminus
    • Additional sequence information

      Mature full length form without signal peptide and propeptide.

Specifications

Our Abpromise guarantee covers the use of ab219423 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 7.40
    Constituents: PBS, 10% Glycerol

General Info

  • Alternative names

    • Alcan beta
    • ALCAN-beta
    • N2DL-1
    • N2DL1
    • N2DL1_HUMAN
    • NKG2D ligand 1
    • NKG2D ligand 1 precursor
    • NKG2DL1
    • RAET1I
    • Retinoic acid early transcript 1I
    • UL16
    • UL16 binding protein 1
    • UL16-binding protein 1
    • ULBP1
    see all
  • Function

    Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
  • Tissue specificity

    Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.
  • Sequence similarities

    Belongs to the MHC class I family.
  • Cellular localization

    Cell membrane. Endoplasmic reticulum. Detected intracellularly in the endoplasmic reticulum of CMV-infected fibroblasts.
  • Information by UniProt

Images

  • 15% SDS-PAGE - Human ULBP1 protein (His tag) (ab219423) at 3 μg.

References

ab219423 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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