Recombinant Human ULBP2 protein (Fc Chimera) (ab185428)

Overview

Description

  • Nature
    Recombinant
  • Source
    Mammalian
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      GRADPHSLCYDITVIPKFRPGPRWCAVQGQVDEKTFLHYDCGNKTVTPVS PLGKKLNVTTAWKAQNPVLREVVDILTEQLRDIQLENYTPKEPLTLQARM SCEQKAEGHSSGSWQFSFDGQIFLLFDSEKRMWTTVHPGARKMKEKWEND KVVAMSFHYFSMGDCIGWLEDFLMGMDSTLEPSAGAPLAMSS
    • Molecular weight
      22 kDa
    • Amino acids
      26 to 217
    • Additional sequence information
      Mature protein. C terminal FC tag.

Specifications

Our Abpromise guarantee covers the use of ab185428 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    HPLC

  • Endotoxin level
    < 1.000 Eu/µg
  • Purity
    >95% by SDS-PAGE .
    Determined by SEC-HPLC and reducing SDS-PAGE.
  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle. Reconstitute for long term storage.

    pH: 7.40
    Constituent: 100% PBS

    Lyophilized from an 0.2 µM filtered solution.

  • Reconstitution
    Dissolve the lyophilized protein in 3X PBS. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

General Info

  • Alternative names
    • ALCAN alpha
    • ALCAN-alpha
    • N2DL 2
    • N2DL-2
    • N2DL2
    • N2DL2_HUMAN
    • NKG2D ligand 2
    • NKG2D ligand 2 precursor
    • NKG2DL2
    • RAET1H
    • Retinoic acid early transcript 1 H
    • Retinoic acid early transcript 1H
    • UL16 binding protein 2
    • UL16-binding protein 2
    • ULBP2
    see all
  • Function
    Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
  • Tissue specificity
    Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues.
  • Sequence similarities
    Belongs to the MHC class I family.
  • Cellular localization
    Cell membrane. Secreted.
  • Information by UniProt

References

ab185428 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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