The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Deubiquitinating enzyme 34
Ubiquitin carboxyl terminal hydrolase 34
Ubiquitin carboxyl-terminal hydrolase 34
Ubiquitin specific processing protease 34
Ubiquitin specific protease 34
Ubiquitin thioesterase 34
Ubiquitin thiolesterase 34
Ubiquitin-specific-processing protease 34
Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquinated proteins.
Expressed in brain at low level.
Belongs to the peptidase C19 family.
Phosphorylated upon DNA damage, probably by ATM or ATR.