Description

  • Product name

    Recombinant Human VDAC2 protein
  • Expression system

    Wheat germ
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MATHGQTCARPMCIPPSYADLGKAARDIFNKGFGFGLVKLDVKTKSCSGV EFSTSGSSNTDTGKVTGTLETKYKWCEYGLTFTEKWNTDNTLGTEIAIED QICQGLKLTFDTTFSPNTGKKSGKIKSSYKRECINLGCDVDFDFAGPAIH GSAVFGYEGWLAGYQMTFDSAKSKLTRNNFAVGYRTGDFQLHTNVNDGTE FGGSIYQKVCEDLDTSVNLAWTSGTNCTRFGIAAKYQLDPTASISAKVNN SSLIGVGYTQTLRPGVKLTLSALVDGKSINAGGHKVGLALELEA
    • Predicted molecular weight

      58 kDa including tags
    • Amino acids

      1 to 294
    • Tags

      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab152793 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 µg/µl.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • B-36 vdac
    • FLJ23841
    • hVDAC2
    • OTTHUMP00000019878
    • OTTHUMP00000019879
    • OTTHUMP00000019880
    • Outer mitochondrial membrane protein porin 2
    • POR
    • Porin-2
    • VDAC 2
    • VDAC-2
    • VDAC2
    • VDAC2_HUMAN
    • Vdac6
    • Voltage dependent anion channel 2
    • Voltage dependent anion selective channel protein 2
    • Voltage-dependent anion-selective channel protein 2
    see all
  • Function

    Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.
  • Tissue specificity

    Expressed in all tissues examined.
  • Sequence similarities

    Belongs to the eukaryotic mitochondrial porin family.
  • Domain

    Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.
  • Cellular localization

    Mitochondrion outer membrane.
  • Information by UniProt

Images

  • 12.5% SDS-PAGE showing ab152793 stained with Coomassie Blue.

References

This product has been referenced in:

  • Aono Y  et al. Sulindac sulfone inhibits the mTORC1 pathway in colon cancer cells by directly targeting voltage-dependent anion channel 1 and 2. Biochem Biophys Res Commun 505:1203-1210 (2018). Read more (PubMed: 30327144) »
See 1 Publication for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab152793.
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