Key features and details
- Expression system: Baculovirus infected Sf9 cells
- Purity: > 80% SDS-PAGE
- Active: Yes
- Tags: GST tag N-Terminus
- Suitable for: SDS-PAGE, Functional Studies
Product nameRecombinant human VE-PTP protein (Active)
See all VE-PTP proteins and peptides
The specific activity of ab268905 was determined to be 4,699 nmol/min/mg in a phosphatase assay using pNPP substrate.
Purity> 80 % SDS-PAGE.
Expression systemBaculovirus infected Sf9 cells
Protein lengthProtein fragment
SequenceMESLGGKCDPTQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLYS DTFFSLPITTESEPLFGAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRE RPSARLSIRRDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNY LLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDD DPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMV TQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGE EQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTV VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTEC QYVYLHQCVRDVLRARKLRSEQENPLFPIYENVNPEYHRDPVYSRH
Molecular weight informationSDS-PAGE molecular weight: ~116kDa.
Amino acids1552 to 1997
TagsGST tag N-Terminus
Additional sequence informationGenBank: NM_002837
Our Abpromise guarantee covers the use of ab268905 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.
Constituents: 0.42% MOPS, 1.74% Sodium chloride, 0.31% Glutathione, 0.004% DTT, 0.002% PMSF, 25% Glycerol (glycerin, glycerine)
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- HPTP BETA
- Phosphacan receptor type B
FunctionPlays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin.
Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
Contains 17 fibronectin type-III domains.
Contains 1 tyrosine-protein phosphatase domain.
- Information by UniProt
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab268905 has not yet been referenced specifically in any publications.