Recombinant Human Versican protein (ab152303)

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SDS-PAGE - Recombinant Human Versican protein (ab152303)

    Key features and details

    • Expression system: Wheat germ
    • Suitable for: WB, SDS-PAGE, ELISA

    Description

    • Product name

      Recombinant Human Versican protein
      See all Versican proteins and peptides

    • Expression system

      Wheat germ

    • Accession

      AAH50524.1

    • Protein length

      Full length protein

    • Animal free

      No

    • Nature

      Recombinant

      • Species

        Human

      • Sequence

        MFINIKSILWMCSTLIVTHALHKVKVGKSPPVRGSLSGKVSLPCHFSTMP TLPPSYNTSEFLRIKWSKIEVDKNGKDLKETTVLVAQNGNIKIGQDYKGR VSVPTHPEAVGDASLTVVKLLASDAGLYRCDVMYGIEDTQDTVSLTVDGV VFHYRAATSRYTLNFEAAQKACLDVGAVIATPEQLFAAYEDGFEQCDAGW LADQTVRYPIRAPRVGCYGDKMGKAGVRTYGFRSPQETYDVYCYVDHLDG DVFHLTVPSKFTFEEAAKECENQDARLATVGELQAAWRNGFDQCDYGWLS DASVRHPVTVARAQCGGGLLGVRTLYRFENQTGFPPPDSRFDAYCFKRKC LIPF

      • Predicted molecular weight

        66 kDa including tags

      • Amino acids

        1 to 354

    Specifications

    Our Abpromise guarantee covers the use of ab152303 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Western blot

      SDS-PAGE

      ELISA

    • Form

      Liquid

    • Additional notes

       

       

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      Constituents: 0.31% Glutathione, 0.79% Tris HCl

    General Info

    • Alternative names

      • Chondroitin sulfate proteoglycan 2
      • Chondroitin sulfate proteoglycan core protein 2
      • Chondroitin sulfate proteoglycan core protein, cartilage
      • CSPG2
      • CSPG2_HUMAN
      • ERVR
      • GHAP
      • Glial hyaluronate binding protein
      • Glial hyaluronate-binding protein
      • Large fibroblast proteoglycan
      • PG-M
      • PGM
      • VCAN
      • Versican
      • Versican core protein
      • Versican proteoglycan
      • WGN
      • WGN 1
      • WGN1
      see all

    • Function

      May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.

    • Tissue specificity

      Cerebral white matter and plasma. Isoform V0 and isoform V1 are expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas. Isoform V2 is restricted to normal brain and gliomas. Isoform V3 is found in all these tissues except medulloblastomas.

    • Involvement in disease

      Defects in VCAN are the cause of Wagner syndrome type 1 (WGN1) [MIM:143200]. WGN is a dominantly inherited vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia. Systemic manifestations are absent in WGN.

    • Sequence similarities

      Belongs to the aggrecan/versican proteoglycan family.
      Contains 1 C-type lectin domain.
      Contains 2 EGF-like domains.
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
      Contains 2 Link domains.
      Contains 1 Sushi (CCP/SCR) domain.

    • Developmental stage

      Disappears after the cartilage development.

    • Post-translational
      modifications

      Phosphorylation sites are present in the extracelllular medium.

    • Cellular localization

      Secreted > extracellular space > extracellular matrix.
    • Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human Versican protein (ab152303)
      SDS-PAGE - Recombinant Human Versican protein (ab152303)
      12.5% SDS-PAGE analysis of ab152303 stained with Coomassie Blue.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab152303? Please let us know so that we can cite the reference in this datasheet.

    ab152303 has not yet been referenced specifically in any publications.

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