Recombinant Human Versican protein (ab152303)

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Overview

Description

  • Nature

    Recombinant

  • Source

    Wheat germ
  • Amino Acid Sequence
    • Accession
      AAH50524.1

    • Species

      Human

    • Sequence

      MFINIKSILWMCSTLIVTHALHKVKVGKSPPVRGSLSGKVSLPCHFSTMP TLPPSYNTSEFLRIKWSKIEVDKNGKDLKETTVLVAQNGNIKIGQDYKGR VSVPTHPEAVGDASLTVVKLLASDAGLYRCDVMYGIEDTQDTVSLTVDGV VFHYRAATSRYTLNFEAAQKACLDVGAVIATPEQLFAAYEDGFEQCDAGW LADQTVRYPIRAPRVGCYGDKMGKAGVRTYGFRSPQETYDVYCYVDHLDG DVFHLTVPSKFTFEEAAKECENQDARLATVGELQAAWRNGFDQCDYGWLS DASVRHPVTVARAQCGGGLLGVRTLYRFENQTGFPPPDSRFDAYCFKRKC LIPF

    • Molecular weight

      66 kDa including tags

    • Amino acids

      1 to 354

Specifications

Our Abpromise guarantee covers the use of ab152303 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

    ELISA

  • Form

    Liquid

  • Additional notes

    Protein concentration is above or equal to 0.05 µg/µl.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • Chondroitin sulfate proteoglycan 2
    • Chondroitin sulfate proteoglycan core protein 2
    • Chondroitin sulfate proteoglycan core protein, cartilage
    • CSPG2
    • CSPG2_HUMAN
    • ERVR
    • GHAP
    • Glial hyaluronate binding protein
    • Glial hyaluronate-binding protein
    • Large fibroblast proteoglycan
    • PG-M
    • PGM
    • VCAN
    • Versican
    • Versican core protein
    • Versican proteoglycan
    • WGN
    • WGN 1
    • WGN1
    see all

  • Function

    May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.

  • Tissue specificity

    Cerebral white matter and plasma. Isoform V0 and isoform V1 are expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas. Isoform V2 is restricted to normal brain and gliomas. Isoform V3 is found in all these tissues except medulloblastomas.

  • Involvement in disease

    Defects in VCAN are the cause of Wagner syndrome type 1 (WGN1) [MIM:143200]. WGN is a dominantly inherited vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia. Systemic manifestations are absent in WGN.

  • Sequence similarities

    Belongs to the aggrecan/versican proteoglycan family.
    Contains 1 C-type lectin domain.
    Contains 2 EGF-like domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    Contains 2 Link domains.
    Contains 1 Sushi (CCP/SCR) domain.

  • Developmental stage

    Disappears after the cartilage development.

  • Post-translational
    modifications

    Phosphorylation sites are present in the extracelllular medium.

  • Cellular localization

    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human Versican protein (ab152303)
    SDS-PAGE - Recombinant Human Versican protein (ab152303)
    12.5% SDS-PAGE analysis of ab152303 stained with Coomassie Blue.

References

ab152303 has not yet been referenced specifically in any publications.

Publishing research using ab152303? Please let us know so that we can cite the reference in this datasheet.

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