The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Putative Wiskott Aldrich syndrome protein family member 4
Suppressor of cyclic-AMP receptor (WASP family)
Verprolin homology domain-containing protein 2
WASP family protein member 2
WASP family protein member 4
WASP family Verprolin homologous protein 2
WASP-family protein member 2
Wiskott-Aldrich syndrome protein family member 2
Wiskott-Aldrich syndrome protein family verprolin-homologous protein
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle.
Belongs to the SCAR/WAVE family. Contains 1 WH2 domain.
Binds and activates the Arp2/3 complex via the C-terminal domain. Interacts with actin via the WH2 domain.
Cytoplasm > cytoskeleton. Cell projection > lamellipodium. At the interface between the lamellipodial actin meshwork and the membrane.