Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
      P61964
    • Species
      Human
    • Sequence
      MGSSHHHHHHSSGLVPRGSHMATEEKKPETEAARAQPTPSSSATQSKPTP VKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN YVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYIL AATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSED NLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW KSDC
    • Molecular weight
      39 kDa including tags
    • Amino acids
      1 to 334
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab98079 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Mass spectrometry
    MALDI-TOF
  • Purity
    > 95 % SDS-PAGE.
    ab98079 was purified using conventional chromatography techniques.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.0308% DTT, 0.316% Tris HCl, 10% Glycerol, 0.58% Sodium chloride

General Info

  • Alternative names
    • 2410008O07Rik
    • AA408785
    • AA960360
    • Big
    • BIG 3
    • BIG3
    • BMP2 induced 3 kb gene protein
    • BMP2 induced gene, 3-KB
    • BMP2-induced 3-kb gene protein
    • MGC114572
    • OTTHUMP00000162494
    • SWD 3
    • SWD3
    • SWD3 Set1c WD40 repeat protein homolog
    • WD repeat containing protein 5
    • WD repeat domain 5
    • WD repeat protein 5
    • WD repeat-containing protein 5
    • WD repeat-containing protein BIG-3
    • WDR 5
    • Wdr5
    • WDR5_HUMAN
    see all
  • Function
    Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.
  • Sequence similarities
    Belongs to the WD repeat WDR5/wds family.
    Contains 7 WD repeats.
  • Cellular localization
    Nucleus.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human WDR5 protein (ab98079)
    SDS-PAGE - Recombinant Human WDR5 protein (ab98079)
    15% SDS-PAGE analysis of 3µg ab98079

References

ab98079 has not yet been referenced specifically in any publications.

Publishing research using ab98079? Please let us know so that we can cite the reference in this datasheet.

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