Overview

  • Product name

    Recombinant human WFIKKN2 protein
  • Protein length

    Full length protein

Description

  • Nature

    Recombinant
  • Source

    CHO cells
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      LPPIRYSHAG ICPNDMNPNL WVDAQSTCRR ECETDQECET YEKCCPNVCG TKSCVAARYM DVKGKKGPVG MPKEATCDHF MCLQQGSECD IWDGQPVCKC KDRCEKEPSF TCASDGLTYY NRCYMDAEAC SKGITLAVVT CRYHFTWPNT SPPPPETTMH PTTASPETPE LDMAAPALLN NPVHQSVTMG ETVSFLCDVV GRPRPEITWE KQLEDRENVV MRPNHVRGNV VVTNIAQLVI YNAQLQDAGI YTCTARNVAG VLRADFPLSV VRGHQAAATS ESSPNGTAFP AAECLKPPDS EDCGEEQTRW HFDAQANNCL TFTFGHCHRN LNHFETYEAC MLACMSGPLA ACSLPALQGP CKAYAPRWAY NSQTGQCQSF VYGGCEGNGN NFESREACEE SCPFPRGNQR CRACKPRQKL VTSFCRSDFV ILGRVSELTE EPDSGRALVT VDEVLKDEKM GLKFLGQEPL EVTLLHVDWA CPCPNVTVSE MPLIIMGEVD GGMAMLRPDS FVGASSARRV RKLREVMHKK TCDVLKEFLG LH
    • Molecular weight

      60 kDa
    • Amino acids

      35 to 576

Specifications

Our Abpromise guarantee covers the use of ab134608 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity

    Determined by its ability to inhibit Human Myostatin (GDF-8) activity in MCP-11 cells. The ED50 for this effect is 0.0025-0.0040 µg/ml in the presence of 5ng/ml of Human Myostatin (GDF-8).
  • Applications

    SDS-PAGE

    HPLC

    Functional Studies

  • Endotoxin level

    < 0.100 Eu/µg
  • Purity

    > 95 % SDS-PAGE.
    Greater than 95% by SDS-PAGE gel and HPLC analyses.
  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 7.80
    Constituent: 0.16% Sodium phosphate

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex.

General Info

  • Alternative names

    • follistatin
    • GASP 1
    • GASP-1
    • Growth and differentiation factor-associated serum protein 1
    • hGASP 1
    • hGASP-1
    • immunoglobulin
    • kazal
    • kunitz and NTR domain-containing protein 2
    • kunitz and NTR domain-containing-related protein
    • UNQ9235/PRO31996
    • WAP
    • WAP follistatin immunoglobulin kunitz and NTR domain containing-related protein
    • WAP kazal immunoglobulin kunitz and NTR domain containing protein 2
    • WFIKKN-related protein
    • Wfikkn2
    • WFKN2_HUMAN
    see all
  • Function

    Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin.
  • Tissue specificity

    Primarily expressed in ovary, testis and brain, but not in liver. In fetal tissues, it is primarily expressed in brain, skeletal muscle, thymus and kidney.
  • Sequence similarities

    Belongs to the WFIKKN family.
    Contains 2 BPTI/Kunitz inhibitor domains.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 Kazal-like domain.
    Contains 1 NTR domain.
    Contains 1 WAP domain.
  • Cellular localization

    Secreted.
  • Information by UniProt

References

ab134608 has not yet been referenced specifically in any publications.

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