Overview

Description

  • Nature

    Recombinant
  • Source

    HEK 293 cells
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Molecular weight

      36 kDa
    • Amino acids

      32 to 349

Associated products

Specifications

Our Abpromise guarantee covers the use of ab129138 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity

    Determined by its ability to inhibit Wnt3a induced alkaline phosphatase production in MC3T3-E1 cells. The expected ED50 for this effect is 40-60 ng/ml.
  • Applications

    Functional Studies

    SDS-PAGE

    HPLC

  • Purity

    > 98 % SDS-PAGE.
    Purity: > 98% by SDS-PAGE and HPLC analysis.
  • Form

    Lyophilised
  • Additional notes

    Endotoxin level: < 0.1 ng/µg of Human Wnt7a.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Store under desiccating conditions.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    Upon reconstitution ab129138 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze-thaw cycles.

General Info

  • Alternative names

    • Protein Wnt-7a
    • Protein Wnt-7a precursor
    • Proto oncogene Wnt7a protein
    • proto-oncogene wnt7a protein
    • wingless-type MMTV integration site family, member 7A
    • Wnt family member 7A
    • WNT7A
    • WNT7A_HUMAN
    see all
  • Function

    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts.
  • Tissue specificity

    Expression is restricted to placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain.
  • Involvement in disease

    Defects in WNT7A are the cause of limb/pelvis-hypoplasia/aplasia syndrome (LPHAS) [MIM:276820]; also known as absence of ulna and fibula with severe limb deficiency. LPHAS is a limb-malformation disorder characterized by various degrees of limb aplasia/hypoplasia and joint dysplasia.
    Defects in WNT7A are a cause of Fuhrmann syndrome (FUHRS) [MIM:228930]; also known as fibular aplasia or hypoplasia femoral bowing and poly- syn- and oligodactyly. Fuhrmann syndrome is a distinct limb-malformation disorder characterized also by various degrees of limb aplasia/hypoplasia and joint dysplasia.
  • Sequence similarities

    Belongs to the Wnt family.
  • Cellular localization

    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt

References

ab129138 has not yet been referenced specifically in any publications.

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