Overview

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Molecular weight

      29 kDa
    • Amino acids

      208 to 480

Specifications

Our Abpromise guarantee covers the use of ab127071 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Additional notes

    Protein previously labeled as TCCR.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration.

General Info

  • Alternative names

    • Class I cytokine receptor
    • CRL1
    • Cytokine receptor-like 1
    • I27RA_HUMAN
    • IL-27 receptor subunit alpha
    • IL-27R subunit alpha
    • IL-27R-alpha
    • IL-27RA
    • IL27R
    • IL27R alpha
    • Il27ra
    • Interleukin 27 receptor
    • Interleukin 27 receptor alpha chain precursor
    • Interleukin-27 receptor subunit alpha
    • Protein CRL1
    • T cell cytokine receptor type 1
    • TCCR
    • Type 1 T cell cytokine receptor
    • Type I T-cell cytokine receptor
    • WSX-1
    • WSX1
    • ZcytoR1
    see all
  • Function

    Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.
  • Tissue specificity

    Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in CD19+ B-cells and monocytes.
  • Sequence similarities

    Belongs to the type I cytokine receptor family. Type 2 subfamily.
    Contains 3 fibronectin type-III domains.
  • Domain

    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • Cellular localization

    Membrane.
  • Information by UniProt

References

ab127071 has not yet been referenced specifically in any publications.

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