Description

  • Product name

    Recombinant human XCL1 protein
    See all XCL1 proteins and peptides
  • Biological activity

    ab229838 activity verified by intracellular calcium flux using HEK 293 cells.

  • Purity

    > 95 % SDS-PAGE.
    ab229838 is expressed in E. coli then processed, refolded and purified to yield the native, secreted form of the mature chemokine. >98% pure by SDS-PAGE, HPLC, MALDI-MS and NMR analysis.
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Predicted molecular weight

      10 kDa
    • Amino acids

      22 to 114
    • Additional sequence information

      Full-length mature protein lacking the signal peptide.

Associated products

Specifications

Our Abpromise guarantee covers the use of ab229838 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Other

    Mass Spectrometry

    HPLC

    SDS-PAGE

    Functional Studies

  • Mass spectrometry

    MALDI-TOF
  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C long term.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    Add deionized water to desired volume, aliquot and freeze unused portion.

General Info

  • Alternative names

    • ATAC
    • Chemokine (C motif) ligand 1
    • Cytokine SCM1
    • LPTN
    • LTN
    • Lymphotactin
    • Lymphotaxin
    • SCM1
    • SCM1 alpha
    • SCM1a
    • SCYC1
    • Small inducible cytokine C1
    • XC chemokine ligand 1
    see all
  • Relevance

    Human lymphotactin (Lptn)/XCL1, also named human SCM1 and ATAC, is a member of gamma or C subfamily of chemokines that lack two of the four invariant cysteine residues normally found in the CC and CXC chemokines and have an extended C-terminus. Human lymphotactin encodes a 114 amino acid precursor protein with a 21 amino acid predicted signal peptide. The gene for human and mouse lymphotactin has been mapped to chromosome 1. Human and mouse lymphotactin share approximately 60% amino acid sequence identity. The expression of lymphotactin is restricted to activated T cells such as activated CD8+ T cells and other class I MHC restricted T cells. Since lymphotactin is produced by lymphocytes and acts on lymphocytes, it is speculated that it is a messenger in T cell chemoattraction. Human lymphotactin is chemotactic for lymphocytes and NK cells. Its expression is abundant in some activated T cells such as activated CD8+ T cells and other class I MCH restricted T cells and is absent in CD4+ T cells. It has been shown that lymphotactin is a key regulator of lymphocyte motility and adhesion during acute allograft rejection. The specific receptor for lymphotactin is the orphan receptor XCR1 (GPR5). It has chemotactic activity for lymphocytes and natural killer cells but not for monocytes or neutrophils.
  • Cellular localization

    Secreted

Images

  • ab229838 activity verified by intracellular calcium flux using HEK 293 cells.

References

ab229838 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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