Recombinant Human ZAN protein (ab159808)

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Description

  • Product name

    Recombinant Human ZAN protein

  • Expression system

    Wheat germ

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      KEKPPDQKLVVRSSRDNYVLTQCDFEDDAKPLCDWSQVSADDEDWVRASG PSPTGSTGAPGGYPNGEGSYLHMESNSFHRGGVARLLSPDLWEQG

    • Amino acids

      19 to 113

    • Tags

      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab159808 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form

    Liquid

  • Additional notes

     

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • OTTHUMP00000211358
    • OTTHUMP00000211359
    • OTTHUMP00000211360
    • OTTHUMP00000211361
    • OTTHUMP00000211362
    • OTTHUMP00000211363
    • ZAN
    • ZAN_HUMAN
    • Zonadhesin
    see all

  • Function

    Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling.

  • Tissue specificity

    In testis, primarily in haploid spermatids.

  • Sequence similarities

    Contains 1 EGF-like domain.
    Contains 3 MAM domains.
    Contains 4 TIL (trypsin inhibitory-like) domains.
    Contains 5 VWFC domains.
    Contains 4 VWFD domains.

  • Domain

    The MAM domains probably mediate sperm adhesion to the zona pellucida.
    During sperm migration through the reproductive tracts, the mucin-like domain might inhibit inappropriate trapping of spermatozoa or promoting adhesion to the oviductal isthmus.
    The VWFD domain 2 may mediate covalent oligomerization.

  • Cellular localization

    Cell membrane. Exclusively on the apical region of the sperm head.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human ZAN protein (ab159808)
    SDS-PAGE - Recombinant Human ZAN protein (ab159808)
    ab159808 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab159808 has not yet been referenced specifically in any publications.

Publishing research using ab159808? Please let us know so that we can cite the reference in this datasheet.

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