Overview

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Molecular weight

      24 kDa
    • Amino acids

      131 to 346
    • Tags

      His-DHFR tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab127120 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration

General Info

  • Alternative names

    • KOX17
    • Retinoic acid suppression protein A
    • RSG A
    • RSG-A
    • RSGA
    • Zfp191
    • Zinc finger and SCAN domain containing protein 3
    • Zinc finger and SCAN domain-containing protein 3
    • Zinc finger protein 191
    • Zinc finger protein 24
    • Zinc finger protein KOX17
    • ZNF 24
    • ZNF191
    • ZNF24
    • ZNF24_HUMAN
    • ZSCAN 3
    • ZSCAN3
    see all
  • Function

    Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro.
  • Tissue specificity

    Expressed in many tissues except in heart.
  • Sequence similarities

    Belongs to the krueppel C2H2-type zinc-finger protein family.
    Contains 4 C2H2-type zinc fingers.
    Contains 1 SCAN box domain.
  • Post-translational
    modifications

    Sumoylated.
  • Cellular localization

    Nucleus.
  • Information by UniProt

References

ab127120 has not yet been referenced specifically in any publications.

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