Product nameRecombinant JCV Polyomavirus Major Capsid VP1 protein
See all JCV Polyomavirus Major Capsid VP1 proteins and peptides
Purity> 95 % SDS-PAGE.
Purified by ultracentifugation.
Expression systemSaccharomyces cerevisiae
Protein lengthFull length protein
Our Abpromise guarantee covers the use of ab74569 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
JCV VP1 protein was purified and lyophilized assembled into virus like particles (VLPs). It is tested for hemagglutination activity and analysed using electron microscopy.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C.
ReconstitutionReconstitute with deionized H2O. After reconstitution store at 4°C.
- Capsid protein VP1
RelevanceThe human polyomavirus JC virus (JCV) infects greater than 80% of the human population. The JC virus is a small (38-40 nm in diameter) double stranded, circular DNA virus covered by an icosahedral capsid. Infection with JCV is asymptomatic and it occurs in early childhood. After the primary infection, the virus remains in latent state in the kidney, until it's reactivation under immunosuppressive conditions to result in Progressive Multifocal Leukoencephalopathy (PML), a fatal demyelinating disease. 70% of all HIV-1- infected patients will exhibit neurological disorders and between 5 and 8% of all HIV-1-infected patients will develop PML. Similar to other polyomaviruses, JCV can cause tumors when intracerebrally inoculated at high titers into developing rodent. Several reports suggest the association of viruses, especially of the polyomavirus family with different types of human brain tumors. Tumorigenecity of JCV is most likely induced by the viral early gene product T-antigen. T-antigen has the capacity to interact with several tumor suppressor proteins, most notably p53, and functionally inactivate these proteins.
Cellular localizationVirion. Nucleus
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab74569 has been referenced in 1 publication.
- López-Moncada F et al. Nucleolar Expression and Chromosomal Associations in Robertsonian Spermatocytes of Mus musculus domesticus. Genes (Basel) 10:N/A (2019). PubMed: 30736350