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    recombinant-menin-protein-ab114387.pdf

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Recombinant Menin protein (ab114387)

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SDS-PAGE - Recombinant Menin protein (ab114387)

    Key features and details

    • Expression system: Wheat germ
    • Suitable for: SDS-PAGE, WB, ELISA

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    Description

    • Product name

      Recombinant Menin protein
      See all Menin proteins and peptides
    • Expression system

      Wheat germ
    • Accession

      O00255-3
    • Protein length

      Full length protein
    • Animal free

      No
    • Nature

      Recombinant
      • Sequence

        MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFL AVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIR GAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFIT GTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWSWLYLKGSYMRCDRK MEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNL ADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRN VREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLL EAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLH VGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGP RRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGS TAQVPAPAASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQS QVQMKKQKVSTPSDYTLSFLKRQRKGL
      • Predicted molecular weight

        89 kDa
      • Amino acids

        1 to 575

    Associated products

    • Related Products

      • Anti-Menin antibody - ChIP Grade (ab31902)

    Specifications

    Our Abpromise guarantee covers the use of ab114387 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

      Western blot

      ELISA

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.3% Glutathione, 0.79% Tris HCl

    General Info

    • Alternative names

      • MEA 1
      • MEA1
      • MEN 1
      • Men1
      • MEN1_HUMAN
      • Menin
      • Multiple Endocrine Adenomatosis 1
      • Multiple Endocrine Neoplasia 1
      • SCG 2
      • SCG2
      • Suppressor Candidate Gene 2
      • Wermer syndrome
      • ZES
      • Zollinger Ellison Syndrome
      see all
    • Function

      Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.
    • Tissue specificity

      Ubiquitous.
    • Involvement in disease

      Defects in MEN1 are the cause of familial multiple endocrine neoplasia type I (MEN1) [MIM:131100]. Autosomal dominant disorder characterized by tumors of the parathyroid glands, gastro-intestinal endocrine tissue, the anterior pituitary and other tissues. Cutaneous lesions and nervous-tissue tumors can exist. Prognosis in MEN1 patients is related to hormonal hypersecretion by tumors, such as hypergastrinemia causing severe peptic ulcer disease (Zollinger-Ellison syndrome, ZES), primary hyperparathyroidism, and acute forms of hyperinsulinemia.
      Defects in MEN1 are the cause of familial isolated hyperparathyroidism (FIHP) [MIM:145000]; also known as hyperparathyroidism type 1 (HRPT1). FIHP is an autosomal dominant disorder characterized by hypercalcemia, elevated parathyroid hormone (PTH) levels, and uniglandular or multiglandular parathyroid tumors.
    • Post-translational
      modifications

      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localization

      Nucleus. Concentrated in nuclear body-like structures. Relocates to the nuclear matrix upon gamma irradiation.
    • Target information above from: UniProt accession O00255 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant Menin protein (ab114387)
      SDS-PAGE - Recombinant Menin protein (ab114387)
      ab114387 analysed on a 12.5% SDS-PAGE Stained with Coomassie Blue.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet download

      Download

    References (0)

    Publishing research using ab114387? Please let us know so that we can cite the reference in this datasheet.

    ab114387 has not yet been referenced specifically in any publications.

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