Overview

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Mouse
    • Sequence

      MGLECDGKVN ICCKKQFFVS FKDIGWNDWI IAPSGYHANY CEGECPSHIA GTSGSSLSFH STVINHYRMR GHSPFANLKS CCVPTKLRPM SMLYYDDGQN IIKKDIQNMI VEECGCS
    • Molecular weight

      26 kDa
    • Amino acids

      309 to 424
    • Additional sequence information

      Activin A is a non-glycosylated homodimer, containing two 117 aa chains. It is a homodimer of 2 beta A chains & is not biologically active until the N ter propeptide is cleaved from each.

Specifications

Our Abpromise guarantee covers the use of ab151688 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity

    The activity is determined by the ability to induce cytoxicity of MPC-11 cells and is typically less than 2 ng/mL.
  • Applications

    Functional Studies

    SDS-PAGE

    HPLC

  • Endotoxin level

    >=1.000 Eu/µg
  • Purity

    >= 95 % SDS-PAGE.
    ab151688 is >95% pure as assessed by HPLC, Reducing and Non-reducing SDS-PAGE.
  • Form

    Lyophilised
  • Additional notes

    This product shares 100% homology with amino acids 309 - 424 of Rat Activin A and amino acids 311 - 426 of Human Activin A. 

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C.

    Constituent: 0.02% Trifluoroacetic acid

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water, which can then be further diluted to other aqueous solutions. Reconstituted material should be aliquoted and frozen at -20°C. It is recommended that a carrier protein (0.1% HSA or BSA) is added for long term storage.

General Info

  • Alternative names

    • Activin A
    • Activin beta A chain
    • Activin beta-A chain
    • ActivinA
    • EDF
    • Erythroid differentiation factor
    • Erythroid differentiation protein
    • follicle stimulating hormone releasing protein
    • FRP
    • FSH releasing factor
    • FSH releasing protein
    • INHBA
    • INHBA_HUMAN
    • Inhibin beta A
    • Inhibin beta A chain
    • Inhibin beta A subunit
    see all
  • Function

    Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
  • Sequence similarities

    Belongs to the TGF-beta family.
  • Cellular localization

    Secreted.
  • Information by UniProt

References

ab151688 has not yet been referenced specifically in any publications.

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