Description

  • Product name

    Recombinant Mouse BTNL2 protein (Fc Chimera)
  • Purity

    >= 98 % SDS-PAGE.

  • Endotoxin level

    < 0.060 Eu/µg
  • Expression system

    CHO cells
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Mouse
    • Amino acids

      26 to 457
    • Additional sequence information

      Recombinant fragment of Isoform 2 fused to the N-terminus of the Fc region of mouse IgG2a.

Specifications

Our Abpromise guarantee covers the use of ab214559 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C long term. Avoid freeze / thaw cycle.

    Constituent: 100% PBS

  • Reconstitution
    Reconstitute at 100 µg/mL in sterile PBS. Working aliquots are stable for up to 3 months when stored at -20°C.

General Info

  • Alternative names

    • BTL-II
    • Btnl2
    • BTNL2_HUMAN
    • Butyrophilin like 2 (MHC class II associated)
    • Butyrophilin-like protein 2
    • DAAP-282D22.2
    • HSBLMHC1
    • SS2
    see all
  • Function

    Negative regulator of T cell proliferation.
  • Tissue specificity

    Expressed in brain, heart, kidney, liver, pancreas, ovary, leukocyte, small intestine, testis and thymus.
  • Involvement in disease

    Genetic variation in BTNL2 is a cause of susceptibility to sarcoidosis type 2 (SS2) [MIM:612387]. Sarcoidosis is an idiopathic, systemic, inflammatory disease characterized by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved. Note=A nucleotide transition affecting a splice donor site results in the use of an alternative splice site and the production of isoform 3. Individuals expressing isoform 3 have a higher risk for sarcoidosis.
  • Sequence similarities

    Belongs to the immunoglobulin superfamily. BTN/MOG family.
    Contains 3 Ig-like V-type (immunoglobulin-like) domains.
  • Cellular localization

    Membrane. Isoform 2 is present in the nuclear, vesicle and plasma membranes, isoform 3 is found in cytoplasmic vesicle structures and is not membrane bound.
  • Information by UniProt

References

ab214559 has not yet been referenced specifically in any publications.

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