Description

  • Product name

    Recombinant mouse CD105 protein
    See all CD105 proteins and peptides
  • Purity

    > 95 % SDS-PAGE.
    Purity: > 95% (SDS-PAGE and visualized by Silverstain) Endotoxin level: < 0.1 ng per µg of CD105
  • Expression system

    Insect cells
  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Mouse
    • Amino acids

      1 to 581

Specifications

Our Abpromise guarantee covers the use of ab54339 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    ELISA

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    None

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    The protein can also be reconstituted in ddH2O or PBS to a concentration of 100µg/ml. The carrier-free protein should be used immediately upon reconstitution to avoid losses in activity due to non-specific binding to the inside surface of the vial. For long term storage as a dilute solution, a carrier protein (e.g. 0.1% HSA or BSA) should be added to the vial.

General Info

  • Alternative names

    • AI528660
    • AI662476
    • CD 105
    • CD105
    • CD105 antigen
    • EGLN_HUMAN
    • END
    • Endoglin
    • Eng
    • FLJ41744
    • HHT1
    • ORW
    • ORW1
    • Osler Rendu Weber syndrome 1
    • RP11 228B15.2
    • S endoglin
    • S-endoglin
    • SN6
    see all
  • Function

    Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.
  • Tissue specificity

    Endoglin is restricted to endothelial cells in all tissues except bone marrow.
  • Involvement in disease

    Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300, 108010]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity.
  • Cellular localization

    Membrane.
  • Information by UniProt

Images

  • SDS-PAGE analysis of recombinant mouse soluble CD105 from insect cells. Sample was loaded in 10% SDS-polyacrylamide gel under reducing conditions and stained with Silver stain.
  • ab54339 on SDS-PAGE

References

ab54339 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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