Description

  • Product name

    Recombinant Mouse CD130 (gp130) protein (Fc Chimera)
    See all CD130 (gp130) proteins and peptides
  • Purity

    > 95 % SDS-PAGE.

  • Endotoxin level

    < 1.000 Eu/µg
  • Expression system

    HEK 293 cells
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Mouse
    • Sequence

      QLLEPCGYIYPEFPVVQRGSNFTAICVLKEACLQHYYVNASYIVWKTNHA AVPREQVTVINRTTSSVTFTDVVLPSVQLTCNILSFGQIEQNVYGVTMLS GFPPDKPTNLTCIVNEGKNMLCQWDPGRETYLETNYTLKSEWATEKFPDC QSKHGTSCMVSYMPTYYVNIEVWVEAENALGKVSSESINFDPVDKVKPTP PYNLSVTNSEELSSILKLSWVSSGLGGLLDLKSDIQYRTKDASTWIQVPL EDTMSPRTSFTVQDLKPFTEYVFRIRSIKDSGKGYWSDWSEEASGTTYED RPSRPPSFWYKTNPSHGQEYRSVRLIWKALPLSEANGKILDYEVILTQSK SVSQTYTVTGTELTVNLTNDRYVASLAARNKVGKSAAAVLTIPSPHVTAA YSVVNLKAFPKDNLLWVEWTPPPKPVSKYILEWCVLSENAPCVEDWQQED ATVNRTHLRGRLLESKCYQITVTPVFATGPGGSESLKAYLKQAAPARGPT VRTKKVGKNEAVLAWDQIPVDDQNGFIRNYSISYRTSVGKEMVVHVDSSH TEYTLSSLSSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIE
    • Predicted molecular weight

      93 kDa including tags
    • Amino acids

      23 to 617
    • Additional sequence information

      Extracellular domain fused with a human IgG1 Fc tag at the C-terminal (NP_034690) .

Specifications

Our Abpromise guarantee covers the use of ab221223 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -80°C. Avoid freeze / thaw cycle.

    pH: 7.50
    Constituents: 0.61% Tris, 0.75% Glycine, 5% Trehalose, L-Arginine, Sodium chloride

  • Reconstitution
    It is recommended to reconstitute the lyophilized protein in sterile deionized water to a final concentration of 1 mg/mL. Solubilize for 30 to 60 minutes at room temperature with occasional gentle mixing. Carrier protein (0.1% HSA or BSA) is strongly recommended for further dilution and long term storage.

General Info

  • Alternative names

    • CD130
    • CD130 antigen
    • CDw130
    • gp130
    • GP130 RAPS
    • IL 6R beta
    • IL-6 receptor subunit beta
    • IL-6R subunit beta
    • IL-6R-beta
    • IL-6RB
    • IL6 ST
    • IL6RB_HUMAN
    • IL6ST
    • Interleukin 6 receptor subunit beta
    • Interleukin receptor beta chain
    • Interleukin-6 receptor subunit beta
    • Interleukin-6 signal transducer
    • Membrane glycoprotein 130
    • Membrane glycoprotein gp130
    • Oncostatin M receptor
    • Oncostatin M receptor alpha subunit
    • Oncostatin-M receptor subunit alpha
    see all
  • Function

    Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.
  • Tissue specificity

    Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells.
  • Sequence similarities

    Belongs to the type I cytokine receptor family. Type 2 subfamily.
    Contains 5 fibronectin type-III domains.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Domain

    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • Post-translational
    modifications

    Phosphorylation of Ser-782 down-regulates cell surface expression.
    Heavily N-glycosylated.
  • Cellular localization

    Secreted and Cell membrane.
  • Information by UniProt

Images

  • SDS-PAGE analysis of reduced ab221223 stained overnight with Coomassie Blue.

    DTT-reduced protein migrates as 120-130 kDa due to glycosylation.

References

ab221223 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab221223.
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