Description

  • Product name

    Recombinant Mouse CD74 protein (Fc Chimera)
    See all CD74 proteins and peptides
  • Purity

    >= 98 % SDS-PAGE.

  • Endotoxin level

    < 5.000 Eu/mg
  • Expression system

    HEK 293 cells
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Mouse
    • Sequence

      QQQGR LDKLTITSQN LQLESLRMKL PKSAKPVSQM RMATPLLMRP MSMDNMLLGP VKNVTKYGNM TQDHVMHLLT RSGPLEYPQL KGTFPENLKH LKNSMDGVNW KIFESWMKQW LLFEMSKNSL EEKKPTEAPP KEPLDMEDLS SGLGVTRQEL GQVTL
    • Predicted molecular weight

      55 kDa including tags
    • Amino acids

      56 to 215
    • Additional sequence information

      The extracellular domain of mouse CD74 (aa 56-215) Short Isoform is fused to the N-terminus of the Fc region of mouse IgG2a (NP_034675.1).

Specifications

Our Abpromise guarantee covers the use of ab214606 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. Stable for 12 months at -20°C.

    Constituent: 100% PBS

    Lyophilized from 0.2µm-filtered solution

  • Reconstitution
    Reconstitute with 100 µl sterile water. Add 1X PBS to the desired protein concentration.

General Info

  • Alternative names

    • CD 74
    • CD74
    • CD74 antigen
    • CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
    • CD74 molecule
    • CD74 molecule, major histocompatibility complex, class II invariant chain
    • CLIP
    • DHLAG
    • Gamma chain of class II antigens
    • HG2A_HUMAN
    • HLA class II histocompatibility antigen gamma chain
    • HLA DR antigens associated invariant chain
    • HLA DR gamma
    • HLA-DR antigens-associated invariant chain
    • HLA-DR-gamma
    • HLADG
    • HLADR antigens associated invariant chain
    • Ia antigen associated invariant chain
    • Ia antigen-associated invariant chain
    • Ia associated invariant chain
    • Ia gamma
    • Ii
    • Invariant polypeptide of major histocompatibility complex class II antigen associated
    • la-gamma
    • Major histocompatibility complex class II invariant chain
    • MHC HLA DR gamma chain
    • MHC HLA-DR gamma chain
    • p33
    • p35
    • Protein 41
    see all
  • Function

    Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
  • Sequence similarities

    Contains 1 thyroglobulin type-1 domain.
  • Cellular localization

    Cell membrane. Endoplasmic reticulum membrane. Golgi apparatus > trans-Golgi network. Endosome. Lysosome. Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.
  • Information by UniProt

References

ab214606 has not yet been referenced specifically in any publications.

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