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Immunology Innate Immunity Macrophage / Inflamm.
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Recombinant Mouse CLECSF6 protein (Tagged) (ab239564)

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SDS-PAGE - Recombinant Mouse CLECSF6 protein (Tagged) (ab239564)

    Key features and details

    • Expression system: Escherichia coli
    • Purity: > 90% SDS-PAGE
    • Suitable for: SDS-PAGE

    Description

    • Product name

      Recombinant Mouse CLECSF6 protein (Tagged)
      See all CLECSF6 proteins and peptides
    • Purity

      > 90 % SDS-PAGE.

    • Expression system

      Escherichia coli
    • Accession

      Q9QZ15
    • Protein length

      Protein fragment
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Mouse
      • Sequence

        QKYSQLLEEKKAAKNIMHNELNCTKSVSPMEDKVWSCCPKDWRLFGSHCY LVPTVSSSASWNKSEENCSRMGAHLVVIQSQEEQDFITGILDTHAAYFIG LWDTGHRQWQWVDQTPYEESITFWHNGEPSSGNEKCATIIYRWKTGWGWN DISCSLKQKSVCQMKKINL
      • Predicted molecular weight

        40 kDa including tags
      • Amino acids

        70 to 238
      • Additional sequence information

        N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged. Extracellular domain.

    Associated products

    • Related Products

      • Anti-6X His tag® antibody [HIS.H8] (ab18184)
      • Anti-Myc tag antibody [9E10] (ab32)
      • Anti-6X His tag® antibody [4D11] (ab5000)
      • Anti-Myc tag antibody (ab9106)
      • Anti-6X His tag® antibody (ab9108)
      • Anti-Myc tag antibody - ChIP Grade (ab9132)

    Specifications

    Our Abpromise guarantee covers the use of ab239564 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

      Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

    General Info

    • Alternative names

      • C type (calcium dependent carbohydrate recognition domain) lectin superfamily member 6
      • C type lectin
      • C type lectin DDB27
      • C type lectin superfamily 6
      • C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6
      • C-type lectin superfamily member 6
      • C-type lectin DDB27
      • C-type lectin domain family 4 member A
      • C-type lectin domain family 4, member A
      • C-type lectin domain family 4, member a2
      • C-type lectin superfamily member 6
      • CLC4A_HUMAN
      • Clec4a
      • Clec4a2
      • CLECSF6
      • DCIR
      • Dcir1
      • DDB27
      • Dendritic cell immunoreceptor
      • HDCGC13P
      • Lectin like immunoreceptor
      • Lectin, C-type, superfamily member 6
      • Lectin-like immunoreceptor
      • LLIR
      see all
    • Function

      May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation.
    • Tissue specificity

      Expressed in dendritic cells, myeloid cells, B-cells and HL-60 cells (at protein level). TNF alpha, IL-1 alpha, and LPS, down-regulated expression at the surface of neutrophils (at protein level). Expressed preferentially in hematopoietic tissues. Expressed in peripheral blood leukocytes, neutrophils, moderate quantities in spleen, lymph node, and bone marrow, and at very low levels in thymus. Expressed in Ag-presenting cells (DC, monocytes, macrophages and B-cells), as well as on granulocytes. Expression was decreased in DC by signals inducing its maturation (e.g. CD40 ligand, LPS, and TNF alpha).
    • Sequence similarities

      Contains 1 C-type lectin domain.
    • Domain

      Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
    • Cellular localization

      Membrane.
    • Target information above from: UniProt accession Q9UMR7 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant Mouse CLECSF6 protein (Tagged) (ab239564)
      SDS-PAGE - Recombinant Mouse CLECSF6 protein (Tagged) (ab239564)

      (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel analysis of ab239564.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab239564? Please let us know so that we can cite the reference in this datasheet.

    ab239564 has not yet been referenced specifically in any publications.

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