Recombinant Mouse CLECSF6 protein (Tagged) (ab239564)
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Description
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Product name
Recombinant Mouse CLECSF6 protein (Tagged)
See all CLECSF6 proteins and peptides -
Purity
> 90 % SDS-PAGE. -
Expression system
Escherichia coli -
Accession
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Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Species
Mouse -
Sequence
QKYSQLLEEKKAAKNIMHNELNCTKSVSPMEDKVWSCCPKDWRLFGSHCY LVPTVSSSASWNKSEENCSRMGAHLVVIQSQEEQDFITGILDTHAAYFIG LWDTGHRQWQWVDQTPYEESITFWHNGEPSSGNEKCATIIYRWKTGWGWN DISCSLKQKSVCQMKKINL -
Predicted molecular weight
40 kDa including tags -
Amino acids
70 to 238 -
Additional sequence information
N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged. Extracellular domain.
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab239564 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
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Form
Liquid -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Constituents: Tris buffer, 50% Glycerol
General Info
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Alternative names
- C type (calcium dependent carbohydrate recognition domain) lectin superfamily member 6
- C type lectin
- C type lectin DDB27
see all -
Function
May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. -
Tissue specificity
Expressed in dendritic cells, myeloid cells, B-cells and HL-60 cells (at protein level). TNF alpha, IL-1 alpha, and LPS, down-regulated expression at the surface of neutrophils (at protein level). Expressed preferentially in hematopoietic tissues. Expressed in peripheral blood leukocytes, neutrophils, moderate quantities in spleen, lymph node, and bone marrow, and at very low levels in thymus. Expressed in Ag-presenting cells (DC, monocytes, macrophages and B-cells), as well as on granulocytes. Expression was decreased in DC by signals inducing its maturation (e.g. CD40 ligand, LPS, and TNF alpha). -
Sequence similarities
Contains 1 C-type lectin domain. -
Domain
Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. -
Cellular localization
Membrane. - Information by UniProt
Images
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SDS-PAGE - Recombinant Mouse CLECSF6 protein (Tagged) (ab239564)(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel analysis of ab239564.
Datasheets and documents
References
ab239564 has not yet been referenced specifically in any publications.
