Recombinant Mouse IL-12 protein (Fc Chimera) (ab215024)

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Description

  • Product name

    Recombinant Mouse IL-12 protein (Fc Chimera)
    See all IL-12 proteins and peptides

  • Purity

    >= 98 % SDS-PAGE.

  • Endotoxin level

    < 0.060 Eu/µg

  • Expression system

    CHO cells

  • Accession

    P43432
    P43431

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Amino Acid Sequence 1

    • Species

      Mouse

    • Sequence

      MCPQKLTISWFAIVLLVSPLMAMWELEKDVYVVEVDWTPDAPGETVNLTC DTPEEDDITWTSDQRHGVIGSGKTLTITVKEFLDAGQYTCHKGGETLSHS HLLLHKKENGIWSTEILKNFKNKTFLKCEAPNYSGRFTCSWLVQRNMDLK FNIKSSSSSPDSRAVTCGMASLSAEKVTLDQRDYEKYSVSCQEDVTCPTA EETLPIELALEARQQNKYENYSTSFFIRDIIKPDPPKNLQMKPLKNSQVE VSWEYPDSWSTPHSYFSLKFFVRIQRKKEKMKETEEGCNQKGAFLVEKTS TEVQCKGGNVCVQAQDRYYNSSCSKWACVPCRVRS

    • Amino acids

      1 to 335

    • Amino Acid Sequence 2

    • Species

      Mouse

    • Sequence

      RVIPVSGPARCLSQSRNLLKTTDDMVKTAREKLKHYSCTAEDIDHEDITR DQTSTLKTCLPLELHKNESCLATRETSSTTRGSCLPPQKTSLMMTLCLGS IYEDLKMYQTEFQAINAALQNHNHQQIILDKGMLVAIDELMQSLNHNGET LRQKPPVGEADPYRVKMKLCILLHAFSTRVVTINRVMGYLSSA

    • Amino acids

      23 to 215

    • Additional sequence information

      Mouse IL-12 complex composed of the p40 subunit (aa 1-335) and the p35 subunit (aa 23-215) (NP_032377.1) is fused through a polypeptide linker to the Fc region of human IgG1.

Specifications

Our Abpromise guarantee covers the use of ab215024 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

    Constituent: 100% PBS

    Lyophilised from 0.2 µm filtered solution.

  • Reconstitution
    Reconstitute at 100µg/ml in sterile PBS.

General Info

  • Alternative names

    • CLMF
    • CLMF p35
    • CLMF p40
    • CLMF1
    • CLMF2
    • Cytotoxic lymphocyte maturation factor 1, p35
    • Cytotoxic lymphocyte maturation factor 2
    • Cytotoxic lymphocyte maturation factor 35 kDa subunit
    • Cytotoxic lymphocyte maturation factor 40 kDa subunit
    • IL 12A
    • IL 2 subunit p40
    • IL-12 subunit p35
    • IL-12A
    • IL-12B
    • IL12
    • IL12, p35 subunit
    • IL12, subunit p40
    • IL12A
    • IL12A_HUMAN
    • IL12B
    • IL35 subunit
    • Interleukin 12 alpha chain
    • Interleukin 12 beta chain
    • Interleukin 12 subunit beta
    • Interleukin 12, p40
    • Interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
    • Interleukin 12B
    • Interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
    • Interleukin-12 subunit alpha
    • Natural killer cell stimulatory factor 1, 35 kD subunit
    • natural killer cell stimulatory factor 2
    • Natural killer cell stimulatory factor, 40 kD subunit
    • NF cell stimulatory factor chain 1
    • NFSK
    • NK cell stimulatory factor chain 1
    • NK cell stimulatory factor chain 2
    • NKSF
    • NKSF1
    • NKSF2
    • P35
    see all

  • Function

    Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.

  • Sequence similarities

    Belongs to the IL-6 superfamily.

  • Cellular localization

    Secreted.
  • Information by UniProt

References

ab215024 has not yet been referenced specifically in any publications.

Publishing research using ab215024? Please let us know so that we can cite the reference in this datasheet.

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