Recombinant Mouse IL-13 receptor alpha 1 protein (Fc Chimera) (ab221227)
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Description
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Product name
Recombinant Mouse IL-13 receptor alpha 1 protein (Fc Chimera)
See all IL-13 receptor alpha 1 proteins and peptides -
Purity
> 95 % SDS-PAGE. -
Endotoxin level
< 1.000 Eu/µg -
Expression system
HEK 293 cells -
Accession
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Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Species
Mouse -
Sequence
ATEVQPPVTNLSVSVENLCTIIWTWSPPEGASPNCTLRYFSHFDDQQDKK IAPETHRKEELPLDEKICLQVGSQCSANESEKPSPLVKKCISPPEGDPES AVTELKCIWHNLSYMKCSWLPGRNTSPDTHYTLYYWYSSLEKSRQCENIY REGQHIACSFKLTKVEPSFEHQNVQIMVKDNAGKIRPSCKIVSLTSYVKP DPPHIKHLLLKNGALLVQWKNPQNFRSRCLTYEVEVNNTQTDRHNILEVE EDKCQNSESDRNMEGTSCFQLPGVLADAVYTVRVRVKTNKLCFDDNKLWS DWSEAQSIGKEQNST -
Predicted molecular weight
63 kDa including tags -
Amino acids
26 to 340 -
Additional sequence information
Fused with a human IgG1 Fc tag at the C-terminus (NP_598751). Extracellular domain.
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Specifications
Our Abpromise guarantee covers the use of ab221227 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
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Form
Lyophilised -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at -80°C. Avoid freeze / thaw cycle.
pH: 7.50
Constituents: 0.61% Tris, 5% Trehalose, 0.75% Glycine, L-Arginine, Sodium chloride -
ReconstitutionIt is recommended to reconstitute the lyophilized protein in sterile deionized water to a final concentration of 1 mg/mL. Solubilize for 30 to 60 minutes at room temperature with occasional gentle mixing. Carrier protein (0.1% HSA or BSA) is strongly recommended for further dilution and long term storage.
General Info
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Alternative names
- bB128O4.2.1 (interleukin 13 receptor, alpha 1)
- Cancer/testis antigen 19
- CD213a1
see all -
Function
Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity. -
Tissue specificity
Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells. -
Sequence similarities
Belongs to the type I cytokine receptor family. Type 5 subfamily. -
Domain
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation. -
Cellular localization
Membrane. - Information by UniProt
Images
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SDS-PAGE - Recombinant Mouse IL-13 receptor alpha 1 protein (Fc Chimera) (ab221227)SDS-PAGE analysis of reduced ab221227 stained overnight with Coomassie Blue.
DTT-reduced protein migrates as 67-100 kDa due to glycosylation.
References
ab221227 has not yet been referenced specifically in any publications.
