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    recombinant-mouse-il-13-receptor-alpha-1-protein-fc-chimera-ab221227.pdf

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Immunology Innate Immunity Cytokines Interleukins
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Recombinant Mouse IL-13 receptor alpha 1 protein (Fc Chimera) (ab221227)

  • Datasheet
  • SDS
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SDS-PAGE - Recombinant Mouse IL-13 receptor alpha 1 protein (Fc Chimera) (ab221227)

    Key features and details

    • Expression system: HEK 293 cells
    • Purity: > 95% SDS-PAGE
    • Endotoxin level: < 1.000 Eu/µg
    • Suitable for: SDS-PAGE

    Description

    • Product name

      Recombinant Mouse IL-13 receptor alpha 1 protein (Fc Chimera)
      See all IL-13 receptor alpha 1 proteins and peptides
    • Purity

      > 95 % SDS-PAGE.

    • Endotoxin level

      < 1.000 Eu/µg
    • Expression system

      HEK 293 cells
    • Accession

      O09030
    • Protein length

      Protein fragment
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Mouse
      • Sequence

        ATEVQPPVTNLSVSVENLCTIIWTWSPPEGASPNCTLRYFSHFDDQQDKK IAPETHRKEELPLDEKICLQVGSQCSANESEKPSPLVKKCISPPEGDPES AVTELKCIWHNLSYMKCSWLPGRNTSPDTHYTLYYWYSSLEKSRQCENIY REGQHIACSFKLTKVEPSFEHQNVQIMVKDNAGKIRPSCKIVSLTSYVKP DPPHIKHLLLKNGALLVQWKNPQNFRSRCLTYEVEVNNTQTDRHNILEVE EDKCQNSESDRNMEGTSCFQLPGVLADAVYTVRVRVKTNKLCFDDNKLWS DWSEAQSIGKEQNST
      • Predicted molecular weight

        63 kDa including tags
      • Amino acids

        26 to 340
      • Additional sequence information

        Fused with a human IgG1 Fc tag at the C-terminus (NP_598751). Extracellular domain.

    Specifications

    Our Abpromise guarantee covers the use of ab221227 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

    • Form

      Lyophilized
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at -80°C. Avoid freeze / thaw cycle.

      pH: 7.4
      Constituents: 0.61% Tris, 5% Trehalose, 0.75% Glycine, L-Arginine, Sodium chloride

    • Reconstitution
      Reconstitute with sterile deionized water to a concentration of 200 µg/ml.

    General Info

    • Alternative names

      • bB128O4.2.1 (interleukin 13 receptor, alpha 1)
      • Cancer/testis antigen 19
      • CD213a1
      • CD213A1 Antigen
      • CT 19
      • CT19
      • I13R1_HUMAN
      • IL 13 receptor subunit alpha 1
      • IL 13R alpha 1
      • IL 13R subunit alpha 1
      • IL 13Ra
      • IL 13RA1
      • IL-13 receptor subunit alpha-1
      • IL-13R subunit alpha-1
      • IL-13R-alpha-1
      • IL-13RA1
      • IL13 receptor alpha 1 chain
      • IL13R
      • IL13RA
      • Il13ra1
      • Interleukin 13 receptor alpha 1
      • Interleukin 13 receptor alpha 1 chain
      • interleukin 13 receptor subunit alpha 1
      • Interleukin-13 receptor subunit alpha-1
      • NR 4
      • NR4
      see all
    • Function

      Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.
    • Tissue specificity

      Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells.
    • Sequence similarities

      Belongs to the type I cytokine receptor family. Type 5 subfamily.
    • Domain

      The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
      The box 1 motif is required for JAK interaction and/or activation.
    • Cellular localization

      Membrane.
    • Target information above from: UniProt accession P78552 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant Mouse IL-13 receptor alpha 1 protein (Fc Chimera) (ab221227)
      SDS-PAGE - Recombinant Mouse IL-13 receptor alpha 1 protein (Fc Chimera) (ab221227)

      SDS-PAGE analysis of reduced ab221227 stained overnight with Coomassie Blue.

      DTT-reduced protein migrates as 67-100 kDa due to glycosylation.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
    • SDS
  • References (0)

    Publishing research using ab221227? Please let us know so that we can cite the reference in this datasheet.

    ab221227 has not yet been referenced specifically in any publications.

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