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Immunology Innate Immunity Cytokines Interleukins
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Bioactive grade

Recombinant mouse IL-16 protein (Active) (ab256040)

  • Datasheet
  • SDS
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SDS-PAGE - Recombinant mouse IL-16 protein (Active) (ab256040)

    Key features and details

    • Expression system: Escherichia coli
    • Purity: > 95% SDS-PAGE
    • Endotoxin level: < 1.000 Eu/µg
    • Active: Yes
    • Suitable for: SDS-PAGE, Functional Studies

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    Description

    • Product name

      Recombinant mouse IL-16 protein (Active)
      See all IL-16 proteins and peptides
    • Biological activity

      Primary human T cell chemotaxis (first detectable at 5 ng/mL).

    • Purity

      > 95 % SDS-PAGE.

    • Endotoxin level

      < 1.000 Eu/µg
    • Expression system

      Escherichia coli
    • Accession

      O54824
    • Protein length

      Protein fragment
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Mouse
      • Sequence

        MHDLNSSTDSAASASAASDISVESKEATVCTVTLEKTSAGLGFSLEGGKG SLHGDKPLTINRIFKGDRTGEMVQPGDEILQLAGTAVQGLTRFEAWNVIK ALPDGPVTIVIRRTSLQCKQTTASADS
      • Predicted molecular weight

        13 kDa
      • Amino acids

        1197 to 1322

    Associated products

      Specifications

      Our Abpromise guarantee covers the use of ab256040 in the following tested applications.

      The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

      • Applications

        SDS-PAGE

        Functional Studies

      • Form

        Lyophilized
      • Concentration information loading...

      Preparation and Storage

      • Stability and Storage

        Shipped at room temperature. Store at -20°C.

        Constituent: 0.16% Sodium phosphate

        This product is an active protein and may elicit a biological response in vivo, handle with caution.

      • Reconstitution
        Reconstitute in sterile water to 0.1 mg/ml. Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

      General Info

      • Alternative names

        • HGNC:5980
        • HsT19289
        • IL-16
        • IL16
        • IL16_HUMAN
        • Interleukin 16 precursor
        • Interleukin-16
        • LCF
        • Lymphocyte chemoattractant factor
        • Neuronal interleukin 16
        • NIL16
        • prIL 16
        • PrIL16
        • Prointerleukin 16
        see all
      • Function

        Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
        Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.
        Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
      • Tissue specificity

        Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T cell proliferation.
      • Sequence similarities

        Contains 4 PDZ (DHR) domains.
      • Post-translational
        modifications

        Isoform 3 is synthesized as a chemo-attractant inactive precursor in hemopoietic tissues and is proteolytically cleaved by caspase-3 to yield IL-16.
      • Cellular localization

        Cytoplasm; Cytoplasm. Nucleus and Secreted.
      • Target information above from: UniProt accession Q14005 The UniProt Consortium
        The Universal Protein Resource (UniProt) in 2010
        Nucleic Acids Res. 38:D142-D148 (2010) .

        Information by UniProt

      Images

      • SDS-PAGE - Recombinant mouse IL-16 protein (Active) (ab256040)
        SDS-PAGE - Recombinant mouse IL-16 protein (Active) (ab256040)

        SDS-PAGE analysis of ab256040 (1μg) under reducing (Lane 1) and non-reducing (Lane 2) conditions. ab256040 is predicted to have a MW of 13.2 kDa

        4-20% Tris-Glycine gel. Coomassie Blue staining.

      Protocols

      To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

      Click here to view the general protocols

      Datasheets and documents

      • Datasheet
      • SDS
    • References (0)

      Publishing research using ab256040? Please let us know so that we can cite the reference in this datasheet.

      ab256040 has not yet been referenced specifically in any publications.

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