Bioactive grade

Recombinant mouse IL36 gamma/IL-1F9 protein (Active) (ab241519)

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Description

  • Product name

    Recombinant mouse IL36 gamma/IL-1F9 protein (Active)
    See all IL36 gamma/IL-1F9 proteins and peptides

  • Biological activity

    Fully biologically active when compared to standard. The ED50 as determined by inducing IL-6 secretion in murine NIH/3T3 cells is less than 10 ng/ml, corresponding to a specific activity of >1.0 x 105 IU/mg.

  • Purity

    > 98 % SDS-PAGE.
    Purity >98% as determined by HPLC

  • Endotoxin level

    < 1.000 Eu/µg

  • Expression system

    Escherichia coli

  • Accession

    Q8R460

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Mouse

    • Sequence

      GRETPDFGEVFDLDQQVWIFRNQALVTVPRSHRVTPVSVTILPCKYPESL EQDKGIAIYLGIQNPDKCLFCKEVNGHPTLLLKEEKILDLYHHPEPMKPF LFYHTRTGGTSTFESVAFPGHYIASSKTGNPIFLTSKKGEYYNINFNLDI KS

    • Predicted molecular weight

      17 kDa

    • Amino acids

      13 to 164

    • Additional sequence information

      Full-length mature chain lacking the pro-peptide.

Specifications

Our Abpromise guarantee covers the use of ab241519 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

    SDS-PAGE

    HPLC

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.50
    Constituents: 0.32% Tris HCl, 0.87% Sodium chloride, 0.02% Tween

    0.2 um filtered

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at = -20 °C. Further dilutions should be made in appropriate buffered solutions.

General Info

  • Alternative names

    • IL 1 epsilon
    • IL 1 related protein 2
    • IL 1(EPSILON)
    • IL 1F9
    • IL 1H1
    • IL 1RP2
    • IL-1 epsilon
    • IL-1-related protein 2
    • IL-1F9
    • IL-1H1
    • IL-1RP2
    • IL1E
    • Il1f9
    • IL1F9_HUMAN
    • IL1H1
    • IL1RP2
    • IL36 gamma
    • IL36G
    • Interleukin 1 epsilon
    • Interleukin 1 family member 9
    • Interleukin 1 homolog 1
    • Interleukin 1 related protein 2
    • Interleukin 36 gamma
    • Interleukin-1 epsilon
    • Interleukin-1 family member 9
    • Interleukin-1 homolog 1
    see all

  • Function

    Function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2. Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.

  • Tissue specificity

    Highly expressed in tissues containing epithelial cells: skin, lung, stomach and esophagus. In skin is expressed only in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Up-regulated in lesional psoriasis skin.

  • Sequence similarities

    Belongs to the IL-1 family.

  • Cellular localization

    Secreted.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant mouse IL36 gamma/IL-1F9 protein (Active) (ab241519)
    SDS-PAGE - Recombinant mouse IL36 gamma/IL-1F9 protein (Active) (ab241519)

    SDS-PAGE - Recombinant mouse IL-36 gamma/IL-1F9 protein (Active) (ab241519)

References

ab241519 has not yet been referenced specifically in any publications.

Publishing research using ab241519? Please let us know so that we can cite the reference in this datasheet.

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