The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
The ED50 as determined by the dose-dependant stimulation of murine 7TD1 cells is < 0.02 ng/ml, corresponding to a Specific Activity of 5 x 107 IU/mg.
% SDS-PAGE. ab73199 is purified by proprietary chromatographic techniques. Purity is greater than 90.0% as determined by SDS-PAGE.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.
pH: 6.00 Constituent: 82% Sodium acetate
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Reconstitute in 20mM HCl to 0.1-1.0 mg/ml to regain full activity, and can then be further diluted to other aqueous solutions.
Interleukin BSF 2
B cell differentiation factor
B cell stimulatory factor 2
B-cell stimulatory factor 2
CTL differentiation factor
Hepatocyte stimulatory factor
Hybridoma growth factor
Hybridoma growth factor Interferon beta-2
Interferon beta 2
Interleukin 6 (interferon beta 2)
Interleukin BSF 2
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.
Involvement in disease
Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.