Recombinant Mouse IRAKM protein (ab245109)

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Description

  • Product name

    Recombinant Mouse IRAKM protein
    See all IRAKM proteins and peptides

  • Purity

    > 85 % SDS-PAGE.

  • Expression system

    Baculovirus

  • Accession

    Q8K4B2

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Mouse

    • Sequence

      MAGRCGARGALSPQLLLFDLPPALLGELCGILDSCDGPLGWRGLAERLSN SWLDVRHIEKYVNQGKSGTRELLWSWAQKNKTIGDLLEVLQDMGHQRAIH LIINYGVSWTPSVQTHHELPFPSFPPEVKHACRENDPGPLEPANVTVDNV LVPEHNEKGTLQKTPISFQSILEGTKHFHKDFLIGEGEIFEVYRVDIRNQ AYAVKLFKQEKKMQLKKHWKRFLSELEVLLLFRHPHILELAAYFTETEKL CLVYPYMSNGTLFDRLQCTNGTTPLSWHVRISVLIGIAKAIQYLHNTQPC AVICGNVSSANILLDDQLQPKLTDFAAAHFRPNLEQQSSTINMTGGGRKH LWYMPEEYIRQGRLSVKTDVYSFGIVIMEVLTGCKVVLDDPKHVQLRDLL MELMEKRGLDSCLSFLDRKIPPCPRNFSAKLFSLAGRCVATKAKLRPTMD EVLSSLESTQPSLYFAEDPPTSLKSFRCPSPLFLDNVPSIPVEDDENQNN HSVPPKEVLGTDRVTQKTPFECSQSEVTFLGLDRNRGNRGSEADCNVPSS SHEECWSPELVAPSQDLSPTVISLGSSWEVPGHSYGSKPMEKRCSSGLFC SEHEQSKKQ

    • Predicted molecular weight

      68 kDa

    • Amino acids

      1 to 609

    • Additional sequence information

      N-terminal 10xHis-tagged and C-terminal Myc-tagged

Specifications

Our Abpromise guarantee covers the use of ab245109 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Constituents: Tris buffer, 50% Glycerol

General Info

  • Alternative names

    • ASRT5
    • IL 1 receptor associated kinase M
    • IL-1 receptor-associated kinase M
    • IL1 receptor associated kinase M
    • Interleukin 1 receptor associated kinase 3
    • Interleukin 1 receptor associated kinase M
    • Interleukin-1 receptor-associated kinase 3
    • IRAK M
    • IRAK-3
    • IRAK-M
    • Irak3
    • IRAK3_HUMAN
    see all

  • Function

    Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.

  • Tissue specificity

    Expressed predominantly in peripheral blood lymphocytes.

  • Involvement in disease

    Defects in IRAK3 are associated with susceptibility to asthma-related traits type 5 (ASRT5) [MIM:611064]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.

  • Sequence similarities

    Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
    Contains 1 death domain.
    Contains 1 protein kinase domain.
  • Information by UniProt

References

ab245109 has not yet been referenced specifically in any publications.

Publishing research using ab245109? Please let us know so that we can cite the reference in this datasheet.

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