Recombinant Mouse IRAKM protein (ab245109)
Key features and details
- Expression system: Baculovirus
- Purity: > 85% SDS-PAGE
- Suitable for: SDS-PAGE
Description
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Product name
Recombinant Mouse IRAKM protein
See all IRAKM proteins and peptides -
Purity
> 85 % SDS-PAGE. -
Expression system
Baculovirus -
Accession
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Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Mouse -
Sequence
MAGRCGARGALSPQLLLFDLPPALLGELCGILDSCDGPLGWRGLAERLSN SWLDVRHIEKYVNQGKSGTRELLWSWAQKNKTIGDLLEVLQDMGHQRAIH LIINYGVSWTPSVQTHHELPFPSFPPEVKHACRENDPGPLEPANVTVDNV LVPEHNEKGTLQKTPISFQSILEGTKHFHKDFLIGEGEIFEVYRVDIRNQ AYAVKLFKQEKKMQLKKHWKRFLSELEVLLLFRHPHILELAAYFTETEKL CLVYPYMSNGTLFDRLQCTNGTTPLSWHVRISVLIGIAKAIQYLHNTQPC AVICGNVSSANILLDDQLQPKLTDFAAAHFRPNLEQQSSTINMTGGGRKH LWYMPEEYIRQGRLSVKTDVYSFGIVIMEVLTGCKVVLDDPKHVQLRDLL MELMEKRGLDSCLSFLDRKIPPCPRNFSAKLFSLAGRCVATKAKLRPTMD EVLSSLESTQPSLYFAEDPPTSLKSFRCPSPLFLDNVPSIPVEDDENQNN HSVPPKEVLGTDRVTQKTPFECSQSEVTFLGLDRNRGNRGSEADCNVPSS SHEECWSPELVAPSQDLSPTVISLGSSWEVPGHSYGSKPMEKRCSSGLFC SEHEQSKKQ -
Predicted molecular weight
68 kDa -
Amino acids
1 to 609 -
Additional sequence information
N-terminal 10xHis-tagged and C-terminal Myc-tagged
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Specifications
Our Abpromise guarantee covers the use of ab245109 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
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Form
Liquid -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)
General Info
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Alternative names
- ASRT5
- IL 1 receptor associated kinase M
- IL-1 receptor-associated kinase M
see all -
Function
Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. -
Tissue specificity
Expressed predominantly in peripheral blood lymphocytes. -
Involvement in disease
Defects in IRAK3 are associated with susceptibility to asthma-related traits type 5 (ASRT5) [MIM:611064]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis. -
Sequence similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
Contains 1 death domain.
Contains 1 protein kinase domain. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
References (0)
ab245109 has not yet been referenced specifically in any publications.