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Bioactive grade

Recombinant mouse Jagged1 protein (Fc Chimera Active) (ab109346)

  • Datasheet
  • SDS
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Key features and details

  • Expression system: HEK 293 cells
  • Purity: > 90% SDS-PAGE
  • Endotoxin level: < 0.010 Eu/µg
  • Active: Yes
  • Tags: Fc tag C-Terminus
  • Suitable for: SDS-PAGE, Inhibition Assay

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Description

  • Product name

    Recombinant mouse Jagged1 protein (Fc Chimera Active)
    See all Jagged1 proteins and peptides
  • Biological activity

    Inhibits adipogenesis in NIH/3T3 cells.

  • Purity

    > 90 % SDS-PAGE.
    ab109346 is lyophilised from a 0.2 µm filtered solution.
  • Endotoxin level

    < 0.010 Eu/µg
  • Expression system

    HEK 293 cells
  • Accession

    Q9QXX0
  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Mouse
    • Predicted molecular weight

      150 kDa including tags
    • Amino acids

      1 to 1067
    • Tags

      Fc tag C-Terminus
    • Additional sequence information

      Signal peptide and extracellular domain of mouse Jagged-1 (aa 1-1067) are fused at the C-terminus to the Fc portion of human IgG.

Associated products

    Specifications

    Our Abpromise guarantee covers the use of ab109346 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

      Inhibition Assay

    • Form

      Lyophilized
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

      Constituent: PBS

      This product is an active protein and may elicit a biological response in vivo, handle with caution.

    • Reconstitution
      For 10µg size: reconstitute with 100µl sterile water. For 50µg size: reconstitute with 50µl sterile water

    General Info

    • Alternative names

      • AGS
      • AHD
      • AWS
      • CD 339
      • CD339
      • CD339 antigen
      • Headturner
      • hJ1
      • Htu
      • Jag 1
      • Jag1
      • JAG1_HUMAN
      • Jagged 1
      • Jagged1
      • Jagged1 (Alagille syndrome)
      • JAGL1
      • MGC104644
      • OTTHUMP00000030278
      • Protein jagged-1
      • Ser 1
      • Ser1
      • Serrate 1
      • Slalom
      see all
    • Function

      Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).
    • Tissue specificity

      Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.
    • Involvement in disease

      Defects in JAG1 are the cause of Alagille syndrome type 1 (ALGS1) [MIM:118450]. Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. There are characteristic facial features and less frequent clinical involvement of the renal and vascular systems.
      Defects in JAG1 are a cause of tetralogy of Fallot (TOF) [MIM:187500]. TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. This condition results in a blue baby at birth due to inadequate oxygenation. Surgical correction is emergent.
    • Sequence similarities

      Contains 1 DSL domain.
      Contains 15 EGF-like domains.
    • Developmental stage

      Expressed in 32-52 days embryos in the distal cardiac outflow tract and pulmonary artery, major arteries, portal vein, optic vesicle, otocyst, branchial arches, metanephros, pancreas, mesocardium, around the major bronchial branches, and in the neural tube.
    • Cellular localization

      Membrane.
    • Target information above from: UniProt accession P78504 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (1)

    Publishing research using ab109346? Please let us know so that we can cite the reference in this datasheet.

    ab109346 has been referenced in 1 publication.

    • Zhu P  et al. Curcumin attenuates hypoxia/reoxygenation-induced cardiomyocyte injury by downregulating Notch signaling. Mol Med Rep 20:1541-1550 (2019). PubMed: 31257466

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