Product nameRecombinant mouse Macrophage Inflammatory Protein 1 beta
See all Macrophage Inflammatory Protein 1 beta proteins and peptides
Protein lengthFull length protein
Amino Acid Sequence
- Anti-Macrophage Inflammatory Protein 1 beta antibody (ab10384)
- Anti-Macrophage Inflammatory Protein 1 beta antibody (ab10386)
- Anti-Macrophage Inflammatory Protein 1 beta antibody (ab25129)
- Anti-Macrophage Inflammatory Protein 1 beta antibody [EPR494] (ab40857)
- Anti-Macrophage Inflammatory Protein 1 beta antibody [EP521Y] (ab45690)
- Anti-Macrophage Inflammatory Protein 1 beta antibody (ab9675)
Our Abpromise guarantee covers the use of ab51978 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Purity> 95 % SDS-PAGE.
PURITY: >98% by SDS-PAGE and HPLC analyses Endotoxin level is <0.1 ng per µg.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Reconstitutionreconstitution in water to a concentration of 0.1-1.0 mg/ml.
- MIP 1 beta
- Secreted protein G 26
- ACT 2
FunctionMonokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
Sequence similaritiesBelongs to the intercrine beta (chemokine CC) family.
modificationsN-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes.
- Information by UniProt
ab51978 has not yet been referenced specifically in any publications.