Recombinant Mouse Ogg1 protein (His tag) (ab222985)
Key features and details
- Expression system: Escherichia coli
- Purity: > 90% SDS-PAGE
- Tags: His tag N-Terminus
- Suitable for: SDS-PAGE, MS
Description
-
Product name
Recombinant Mouse Ogg1 protein (His tag)
See all Ogg1 proteins and peptides -
Purity
> 90 % SDS-PAGE.
ab222985 was purified using conventional chromatography techniques. -
Expression system
Escherichia coli -
Accession
-
Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
-
Species
Mouse -
Sequence
MGSSHHHHHHSSGLVPRGSHMGSMLFRSWLPSSMRHRTLSSSPALWASIP CPRSELRLDLVLASGQSFRWKEQSPAHWSGVLADQVWTLTQTEDQLYCTV YRGDDSQVSRPTLEELETLHKYFQLDVSLAQLYSHWASVDSHFQRVAQKF QGVRLLRQDPTECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVT YHGFPNLHALAGPEAETHLRKLGLGYRARYVRASAKAILEEQGGPAWLQQ LRVAPYEEAHKALCTLPGVGAKVADCICLMALDKPQAVPVDVHVWQIAHR DYGWHPKTSQAKGPSPLANKELGNFFRNLWGPYAGWAQAVLFSADLRQPS LSREPPAKRKKGSKRPEG -
Predicted molecular weight
41 kDa including tags -
Amino acids
1 to 345 -
Tags
His tag N-Terminus -
Additional sequence information
NP_035087.
-
Associated products
-
Related Products
Specifications
Our Abpromise guarantee covers the use of ab222985 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
-
Applications
SDS-PAGE
Mass Spectrometry
-
Form
Liquid -
Concentration information loading...
Preparation and Storage
-
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 7.40
Constituents: 30% Glycerol (glycerin, glycerine), PBS
General Info
-
Alternative names
- 8 hydroxyguanine DNA glycosylase
- 8 oxoguanine DNA glycosylase
- 8 oxoguanine DNA glycosylase 1
see all -
Function
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. -
Tissue specificity
Ubiquitous. -
Involvement in disease
Defects in OGG1 may be a cause of renal cell carcinoma (RCC) [MIM:144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. -
Sequence similarities
Belongs to the type-1 OGG1 family. -
Cellular localization
Mitochondrion; Nucleus and Nucleus > nucleoplasm. Nucleus speckle. Nucleus matrix. Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
-
SDS download
-
Datasheet download
References (0)
ab222985 has not yet been referenced specifically in any publications.