Recombinant Mouse PD-L1 protein (ab130039)

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SDS-PAGE - Recombinant Mouse PD-L1 protein (ab130039)

    Key features and details

    • Expression system: Escherichia coli
    • Purity: > 85% SDS-PAGE
    • Tags: His tag N-Terminus
    • Suitable for: SDS-PAGE, MS

    Description

    • Product name

      Recombinant Mouse PD-L1 protein
      See all PD-L1 proteins and peptides

    • Purity

      > 85 % SDS-PAGE.
      ab130039 is purified using conventional chromatography.

    • Expression system

      Escherichia coli

    • Accession

      Q9EP73

    • Protein length

      Protein fragment

    • Animal free

      No

    • Nature

      Recombinant

      • Species

        Mouse

      • Sequence

        MGSSHHHHHH SSGLVPRGSH MGSHMFTITA PKDLYVVEYG SNVTMECRFP VERELDLLAL VVYWEKEDEQ VIQFVAGEED LKPQHSNFRG RASLPKDQLL KGNAALQITD VKLQDAGVYC CIISYGGADY KRITLKVNAP YRKINQRISV DPATSEHELI CQAEGYPEAE VIWTNSDHQP VSGKRSVTTS RTEGMLLNVT SSLRVNATAN DVFYCTFWRS QPGQNHTAEL IIPELPATHP PQNRTH

      • Predicted molecular weight

        28 kDa including tags

      • Amino acids

        19 to 239

      • Tags

        His tag N-Terminus

    Specifications

    Our Abpromise guarantee covers the use of ab130039 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

      Mass Spectrometry

    • Mass spectrometry

      MALDI-TOF

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

      pH: 8.00
      Constituents: 0.32% Tris HCl, 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride

    General Info

    • Alternative names

      • B7 H
      • B7 H1
      • B7 homolog 1
      • B7-H1
      • B7H
      • B7H1
      • CD 274
      • CD-274
      • CD274
      • CD274 antigen
      • CD274 molecule
      • MGC142294
      • MGC142296
      • OTTHUMP00000021029
      • PD L1
      • PD-L1
      • PD1L1_HUMAN
      • PDCD1 ligand 1
      • PDCD1L1
      • PDCD1LG1
      • PDL 1
      • PDL1
      • Programmed cell death 1 ligand 1
      • Programmed death ligand 1
      • RGD1566211
      see all

    • Function

      Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.

    • Tissue specificity

      Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.

    • Sequence similarities

      Belongs to the immunoglobulin superfamily. BTN/MOG family.
      Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.

    • Cellular localization

      Cell membrane and Endomembrane system.
    • Information by UniProt

    Images

    • SDS-PAGE - Recombinant Mouse PD-L1 protein (ab130039)
      SDS-PAGE - Recombinant Mouse PD-L1 protein (ab130039)
      15% SDS-PAGE analysis of ab130039 (3µg).

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (1)

    Publishing research using ab130039? Please let us know so that we can cite the reference in this datasheet.

    ab130039 has been referenced in 1 publication.

    • Wang G  et al. An engineered oncolytic virus expressing PD-L1 inhibitors activates tumor neoantigen-specific T cell responses. Nat Commun 11:1395 (2020). PubMed: 32170083

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