Bioactive grade

Recombinant mouse Peroxiredoxin 1/PAG protein (Active) (ab219223)

Description

  • Product name

    Recombinant mouse Peroxiredoxin 1/PAG protein (Active)
    See all Peroxiredoxin 1/PAG proteins and peptides
  • Biological activity

    Specific activity is >2,500 pmol/min/μg. Enzymatic activity is defined as the amount of hydroperoxide that 1μg of enzyme can reduce at 25°C for minute.

  • Purity

    > 90 % SDS-PAGE.
    purified by using conventional chromatography techniques.
  • Endotoxin level

    < 1.000 Eu/µg
  • Expression system

    Baculovirus infected insect cells
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Mouse
    • Predicted molecular weight

      23 kDa including tags
    • Amino acids

      1 to 199
    • Tags

      His tag C-Terminus

Specifications

Our Abpromise guarantee covers the use of ab219223 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Functional Studies

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

    pH: 7.4
    Constituents: 90% PBS, 10% Glycerol

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • Heme binding 23 kDa protein
    • MSP23
    • Natural killer cell-enhancing factor A
    • NKEF A
    • NKEF-A
    • NKEFA
    • OSF3
    • Osteoblast specific factor 3
    • PAG
    • Paga
    • PAGB
    • Peroxiredoxin 1
    • Peroxiredoxin-1
    • PRDX1
    • PRDX1_HUMAN
    • Proliferation associated gene A
    • Proliferation-associated gene protein
    • PRX1
    • PrxI
    • TDPX2
    • Thioredoxin peroxidase 2
    • Thioredoxin-dependent peroxide reductase 2
    see all
  • Function

    Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation.
  • Sequence similarities

    Belongs to the ahpC/TSA family.
    Contains 1 thioredoxin domain.
  • Post-translational
    modifications

    Phosphorylated on Thr-90 during the M-phase, which leads to a more than 80% decrease in enzymatic activity.
  • Cellular localization

    Cytoplasm. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt

Images

  • 15% SDS-PAGE (3μg)

References

ab219223 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab219223.
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