Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Placenta growth factor
Placental growth factor
Placental growth factor, vascular endothelial growth factor related protein
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner.
While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas.
Belongs to the PDGF/VEGF growth factor family.
Isoform PlGF-2 contains a basic insert which acts as a cell retention signal.
Secreted. The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.