• Nature

  • Source

    Baculovirus infected insect cells
  • Amino Acid Sequence
    • Accession
    • Species

    • Molecular weight

      81 kDa including tags
    • Amino acids

      45 to 752
    • Tags

      His tag C-Terminus
    • Additional sequence information



Our Abpromise guarantee covers the use of ab219283 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications


  • Endotoxin level

    < 1.000 Eu/µg
  • Purity

    > 85 % SDS-PAGE.
    ab219283 was purified using conventional chromatography techniques.
  • Form

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 7.40
    Constituents: 90% PBS, 10% Glycerol

General Info

  • Alternative names

    • Cell growth inhibiting protein 27
    • Cell growth-inhibiting gene 27 protein
    • FGCP
    • Folate hydrolase
    • Folate hydrolase (prostate-specific membrane antigen) 1
    • Folate hydrolase 1
    • Folate hydrolase prostate specific membrane antigen 1
    • FOLH
    • FOLH 1
    • Folh1
    • Folylpoly gamma glutamate carboxypeptidase
    • Folylpoly-gamma-glutamate carboxypeptidase
    • GCP 2
    • GCP II
    • GCP2
    • GCPII
    • GIG27
    • Glutamate carboxylase II
    • Glutamate carboxypeptidase 2
    • Glutamate carboxypeptidase II
    • Membrane glutamate carboxypeptidase
    • mGCP
    • N acetylated alpha linked acidic dipeptidase 1
    • N-acetylated-alpha-linked acidic dipeptidase I
    • NAALAD 1
    • NAALAD1
    • NAALAdase
    • NAALADase I
    • Prostate specific membrane antigen
    • Prostate specific membrane antigen variant F
    • Prostate-specific membrane antigen
    • PSM
    • PSMA
    • Pteroylpoly gamma glutamate carboxypeptidase
    • Pteroylpoly-gamma-glutamate carboxypeptidase
    see all
  • Function

    Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression.
    Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.
  • Tissue specificity

    Highly expressed in prostate epithelium. Detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). Detected in the small intestine, brain, kidney, liver, spleen, colon, trachea, spinal cord and the capillary endothelium of a variety of tumors. Expressed specifically in jejunum brush border membranes. In the brain, highly expressed in the ventral striatum and brain stem. Also expressed in fetal liver and kidney. Isoform PSMA' is the most abundant form in normal prostate. Isoform PSMA-1 is the most abundant form in primary prostate tumors. Isoform PSMA-2 is also found in normal prostate as well as in brain and liver. Isoform PSMA-9 is specifically expressed in prostate cancer.
  • Sequence similarities

    Belongs to the peptidase M28 family. M28B subfamily.
  • Domain

    The NAALADase activity is found in the central region, the dipeptidyl peptidase IV type activity in the C-terminal.
  • Post-translational

    The first two amino acids at the N-terminus of isoform PSMA' appear to be cleaved by limited proteolysis.
    The N-terminus is blocked.
  • Cellular localization

    Cytoplasm and Cell membrane.
  • Information by UniProt


  • 15% SDS-PAGEanalysis of ab219283 (3μg).


ab219283 has not yet been referenced specifically in any publications.

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