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    recombinant-mouse-rankl-protein-ab151200.pdf

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Immunology Innate Immunity Cytokines TNF Superfamily
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Recombinant Mouse RANKL protein (ab151200)

  • Datasheet
  • SDS
Submit a review Submit a question References (1)

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Abpromise

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Key features and details

  • Expression system: Yeast
  • Purity: > 95% SDS-PAGE
  • Suitable for: SDS-PAGE

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ELISA
Product image
Mouse RANKL ELISA Kit (TNFSF11) (ab100749)

View more associated products

Description

  • Product name

    Recombinant Mouse RANKL protein
    See all RANKL proteins and peptides
  • Purity

    > 95 % SDS-PAGE.
    ab151200 was purified by Ion-exchange Chromatography.
  • Expression system

    Yeast
  • Accession

    O35235
  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Mouse
    • Sequence

      FSGAPAMMEG SWLDVAQRGK PEAQPFAHLT INAASIPSGS HKVTLSSWYH DRGWAKISNM TLSNGKLRVN QDGFYYLYAN ICFRHHETSG SVPTDYLQLM VYVVKTSIKI PSSHNLMKGG STKNWSGNSE FHFYSINVGG FFKLRAGEEI SIQVSNPSLL DPDQDATYFG AFKVQDID
    • Predicted molecular weight

      20 kDa
    • Amino acids

      139 to 316

Associated products

    Specifications

    Our Abpromise guarantee covers the use of ab151200 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

    • Form

      Lyophilized
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

      Constituents: 89% PBS, 10% Trehalose

    • Reconstitution
      Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.

    General Info

    • Alternative names

      • CD254
      • hRANKL2
      • ODF
      • OPGL
      • OPTB2
      • Osteoclast differentiation factor
      • Osteoprotegerin ligand
      • Rank Ligand
      • RANKL
      • Receptor activator of nuclear factor kappa B ligand
      • Receptor activator of nuclear factor kappa-B ligand
      • sOdf
      • TNF related activation induced cytokine
      • TNF-related activation-induced cytokine
      • TNF11_HUMAN
      • TNFSF 11
      • Tnfsf11
      • TRANCE
      • Tumor necrosis factor (ligand) superfamily member 11
      • Tumor necrosis factor ligand superfamily member 11
      • Tumor necrosis factor ligand superfamily member 11, soluble form
      see all
    • Function

      Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.
    • Tissue specificity

      Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid.
    • Involvement in disease

      Defects in TNFSF11 are the cause of osteopetrosis autosomal recessive type 2 (OPTB2) [MIM:259710]; also known as osteoclast-poor osteopetrosis. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB2 is characterized by paucity of osteoclasts, suggesting a molecular defect in osteoclast development.
    • Sequence similarities

      Belongs to the tumor necrosis factor family.
    • Post-translational
      modifications

      The soluble form of isoform 1 derives from the membrane form by proteolytic processing (By similarity). The cleavage may be catalyzed by ADAM17.
    • Cellular localization

      Cytoplasm; Secreted and Cell membrane.
    • Target information above from: UniProt accession O14788 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (1)

    Publishing research using ab151200? Please let us know so that we can cite the reference in this datasheet.

    ab151200 has been referenced in 1 publication.

    • Hosseini H  et al. Early dissemination seeds metastasis in breast cancer. Nature 540:552-558 (2016). PubMed: 27974799

    Customer reviews and Q&As

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