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Immunology Innate Immunity Chemokines Alpha Chemokines (CXC)
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Recombinant mouse SDF1 alpha protein (ab51939)

  • Datasheet
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SDS-PAGE - Recombinant mouse SDF1 alpha protein (ab51939)

    Key features and details

    • Expression system: Escherichia coli
    • Purity: > 99% SDS-PAGE
    • Active: Yes
    • Suitable for: SDS-PAGE, Functional Studies

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    Mouse SDF1 ELISA Kit (ab100741)

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    Description

    • Product name

      Recombinant mouse SDF1 alpha protein
      See all SDF1 alpha proteins and peptides
    • Biological activity

      Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 50-100 ng/ml.

    • Purity

      > 99 % SDS-PAGE.
      >99% by SDS-PAGE and HPLC analyses. Endotoxin level is <0.1 ng per µg (1EU/µg).
    • Expression system

      Escherichia coli
    • Accession

      P40224
    • Protein length

      Full length protein
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Mouse
      • Sequence

        KPVSLSYRCP CRFFESHIAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNK
      • Predicted molecular weight

        8 kDa
      • Amino acids

        22 to 89
      • Additional sequence information

        Mature full length for alpha isoform.

    Associated products

    • Related Products

      • Anti-SDF1 antibody (ab25117)

    Specifications

    Our Abpromise guarantee covers the use of ab51939 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

      Functional Studies

    • Form

      Lyophilized
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

      Constituent: 0.06% Acetic acid

      This product is an active protein and may elicit a biological response in vivo, handle with caution.

    • Reconstitution
      We recommend a quick spin followed by reconstitution in sterile distilled water to a concentration of 0.1-1.0 mg/ml. (The protein may appear as a haze or film, which is difficult to see at the bottom of the vial.)

    General Info

    • Alternative names

      • C-X-C motif chemokine 12
      • Chemokine (C-X-C motif) ligand 12
      • cxcl12
      • hIRH
      • hSDF-1
      • Intercrine reduced in hepatomas
      • IRH
      • PBSF
      • Pre-B cell growth-stimulating factor
      • SCYB12
      • SDF 1 alpha
      • SDF-1
      • SDF-1-alpha(3-67)
      • SDF1
      • SDF1_HUMAN
      • SDF1a
      • SDF1B
      • Stromal cell derived factor 1
      • TLSF
      • TPAR1
      see all
    • Function

      Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the Lyn kinase. Stimulates migration of monocytes through its receptor, CXCR4, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through Lyn kinase.
    • Sequence similarities

      Belongs to the intercrine alpha (chemokine CxC) family.
    • Post-translational
      modifications

      Processed forms SDF-1-beta(3-72) and SDF-1-alpha(3-67) are produced after secretion by proteolytic cleavage of isoforms Beta and Alpha, respectively. The N-terminal processing is probably achieved by DPP4. Isoform Alpha is first cleaved at the C-terminus to yield a SDF-1-alpha(1-67) intermediate before being processsed at the N-terminus. The C-terminal processing of isoform Alpha is reduced by binding to heparin and, probably, cell surface proteoglycans.
    • Cellular localization

      Secreted.
    • Target information above from: UniProt accession P48061 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant mouse SDF1 alpha protein (ab51939)
      SDS-PAGE - Recombinant mouse SDF1 alpha protein (ab51939)

      Purity of ab51939 (2 µg) was analyzed by SDS-PAGE electrophoresis.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (2)

    Publishing research using ab51939? Please let us know so that we can cite the reference in this datasheet.

    ab51939 has been referenced in 2 publications.

    • Archacka K  et al. Beneficial Effect of IL-4 and SDF-1 on Myogenic Potential of Mouse and Human Adipose Tissue-Derived Stromal Cells. Cells 9:N/A (2020). PubMed: 32560483
    • Wu M  et al. JAM-A promotes wound healing by enhancing both homing and secretory activities of mesenchymal stem cells. Clin Sci (Lond) 129:575-88 (2015). PubMed: 25994236

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