Description

  • Product name

    Recombinant Mouse TWEAK protein
    See all TWEAK proteins and peptides
  • Expression system

    Yeast
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Mouse
    • Sequence

      SAPKGRKARP RRAIAAHYEV HPRPGQDGAQ AGVDGTVSGW EETKINSSSP LRYDRQIGEF TVIRAGLYYL YCQVHFDEGK AVYLKLDLLV NGVLALRCLE EFSATAASSP GPQLRLCQVS GLLPLRPGSS LRIRTLPWAH LKAAPFLTYF GLFQVH
    • Predicted molecular weight

      17 kDa
    • Amino acids

      94 to 249
    • Additional sequence information

      Amino acids 94 to 249 represent the chain for the secreted form of mouse TWEAK.

Specifications

Our Abpromise guarantee covers the use of ab184591 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    ELISA

    Western blot

  • Form

    Lyophilised
  • Additional notes

    Mouse TWEAK was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon reconsitution add a carrier protein (0.1% BSA). Store at -20°C long term. Avoid freeze / thaw cycle.

  • Reconstitution
    Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.

General Info

  • Alternative names

    • APO 3 ligand
    • APO 3L
    • APO3 ligand
    • APO3/DR3 ligand
    • APO3L
    • DR3LG
    • MGC129581
    • MGC20669
    • secreted form
    • TNF-related weak inducer of apoptosis
    • TNF12_HUMAN
    • TNFSF 12
    • Tnfsf12
    • TNFSF12 protein
    • Tumor necrosis factor (ligand) superfamily member 12
    • Tumor necrosis factor ligand superfamily member 12
    • Tumor necrosis factor superfamily member 12
    • TWEAK
    • UNQ181/PRO207
    see all
  • Function

    Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines.
  • Tissue specificity

    Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain.
  • Sequence similarities

    Belongs to the tumor necrosis factor family.
  • Post-translational
    modifications

    The soluble form derives from the membrane form by proteolytic processing.
  • Cellular localization

    Secreted and Cell membrane.
  • Information by UniProt

References

This product has been referenced in:

  • Sheng Z  et al. TWEAK promotes endothelial progenitor cell vasculogenesis to alleviate acute myocardial infarction via the Fn14-NF-?B signaling pathway. Exp Ther Med 16:4019-4029 (2018). Read more (PubMed: 30344680) »
See 1 Publication for this product

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