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    recombinant-mouse-tyrosine-hydroxylase-protein-his-tag-ab219278.pdf

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Recombinant Mouse Tyrosine Hydroxylase protein (His tag) (ab219278)

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SDS-PAGE - Recombinant Mouse Tyrosine Hydroxylase protein (His tag) (ab219278)

    Key features and details

    • Expression system: Baculovirus infected insect cells
    • Purity: > 90% SDS-PAGE
    • Endotoxin level: < 1.000 Eu/µg
    • Tags: His tag C-Terminus
    • Suitable for: SDS-PAGE

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    Description

    • Product name

      Recombinant Mouse Tyrosine Hydroxylase protein (His tag)
      See all Tyrosine Hydroxylase proteins and peptides
    • Purity

      > 90 % SDS-PAGE.
      Affinity purified
    • Endotoxin level

      < 1.000 Eu/µg
    • Expression system

      Baculovirus infected insect cells
    • Accession

      P24529
    • Protein length

      Full length protein
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Mouse
      • Sequence

        ADPMPTPSAS SPQPKGFRRA VSEQDTKQAE AVTSPRFIGR RQSLIEDARK EREAAAAAAA AAVASAEPGN PLEAVVFEER DGNAVLNLLF SLRGTKPSSL SRALKVFETF EAKIHHLETR PAQRPLAGSP HLEYFVRFEV PSGDLAALLS SVRRVSDDVR SAREDKVPWF PRKVSELDKC HHLVTKFDPD LDLDHPGFSD QAYRQRRKLI AEIAFQYKQG EPIPHVEYTK EEIATWKEVY ATLKGLYATH ACREHLEAFQ LLERYCGYRE DSIPQLEDVS HFLKERTGFQ LRPVAGLLSA RDFLASLAFR VFQCTQYIRH ASSPMHSPEP DCCHELLGHV PMLADRTFAQ FSQDIGLASL GASDEEIEKL STVYWFTVEF GLCKQNGELK AYGAGLLSSY GELLHSLSEE PEVRAFDPDT AAVQPYQDQT YQPVYFVSES FSDAKDKLRN YASRIQRPFS VKFDPYTLAI DVLDSPHTIR RSLEGVQDEL HTLTQALSAI SHHHHHH
      • Predicted molecular weight

        57 kDa including tags
      • Amino acids

        1 to 498
      • Tags

        His tag C-Terminus

    Associated products

    • Related Products

      • Anti-6X His tag® antibody [HIS.H8] (ab18184)
      • Anti-6X His tag® antibody [4D11] (ab5000)
      • Anti-6X His tag® antibody (ab9108)

    Specifications

    Our Abpromise guarantee covers the use of ab219278 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

      pH: 7.40
      Constituents: 90% PBS, 10% Glycerol (glycerin, glycerine)

    General Info

    • Alternative names

      • Dystonia 14
      • DYT14
      • DYT5b
      • EC 1.14.16.2
      • OTTHUMP00000011225
      • OTTHUMP00000011226
      • ple
      • Protein Pale
      • TH
      • The
      • TY3H_HUMAN
      • TYH
      • Tyrosine 3 hydroxylase
      • Tyrosine 3 monooxygenase
      • Tyrosine 3-hydroxylase
      • Tyrosine 3-monooxygenase
      • Tyrosine hydroxylase
      see all
    • Function

      Plays an important role in the physiology of adrenergic neurons.
    • Tissue specificity

      Mainly expressed in the brain and adrenal glands.
    • Pathway

      Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2.
    • Involvement in disease

      Defects in TH are the cause of dystonia DOPA-responsive autosomal recessive (ARDRD) [MIM:605407]; also known as autosomal recessive Segawa syndrome. ARDRD is a form of DOPA-responsive dystonia presenting in infancy or early childhood. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Some cases of ARDRD present with parkinsonian symptoms in infancy. Unlike all other forms of dystonia, it is an eminently treatable condition, due to a favorable response to L-DOPA.
      Note=May play a role in the pathogenesis of Parkinson disease (PD). A genome-wide copy number variation analysis has identified a 34 kilobase deletion over the TH gene in a PD patient but not in any controls.
    • Sequence similarities

      Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
    • Target information above from: UniProt accession P07101 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant Mouse Tyrosine Hydroxylase protein (His tag) (ab219278)
      SDS-PAGE - Recombinant Mouse Tyrosine Hydroxylase protein (His tag) (ab219278)

      15% SDS-PAGE - Recombinant Mouse Tyrosine Hydroxylase protein (His tag) (ab219278) at 3 μg.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet download

      Download

    References (0)

    Publishing research using ab219278? Please let us know so that we can cite the reference in this datasheet.

    ab219278 has not yet been referenced specifically in any publications.

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