Recombinant OPRT protein (Tagged) (ab240863)

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Description

  • Product name

    Recombinant OPRT protein (Tagged)
    See all OPRT proteins and peptides

  • Purity

    > 90 % SDS-PAGE.

  • Expression system

    Yeast

  • Accession

    P0CS95

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Sequence

      MSSQALDSAKVAFIEAAIEHGVLLFGNFTLKSGRQSPYFFNAGLLYSSSL LSTTAQAYAKVLSSSRIPDFDVLFGPAYKGISLAAVSAVSLYQQTGKDIG YCYNRKEKKDHGEGGTMVGAPLKGRIVIIDDVLTSGKAIREAIDILKASP EAKLVGIVQLVDRQEKGQSGSGKSTVQEVEEEFGVPVEPIIGLDDIVKYL ESSGKWEKELQEVRKYRAEYGVQRS

    • Predicted molecular weight

      28 kDa including tags

    • Amino acids

      1 to 225

    • Additional sequence information

      Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans). N-terminal 10xHis-tagged and C-terminal Myc-tagged.

Specifications

Our Abpromise guarantee covers the use of ab240863 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid

  • Additional notes

     This product was previously labelled as UMPS

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Constituents: Tris buffer, 50% Glycerol

General Info

  • Alternative names

    • ODC
    • OMPdecase
    • OPRT
    • OPRTase
    • Orotate phosphoribosyl transferase and orotidine 5' decarboxylase
    • Orotate phosphoribosyltransferase
    • Orotate phosphoribosyltransferase phosphoribosyltransferase
    • Orotidine 5' phosphate decarboxylase
    • Orotidine 5''-phosphate decarboxylase
    • RP11-71H17.9
    • UMP synthase
    • Umps
    • UMPS_HUMAN
    • Uridine 5' monophosphate synthase
    • Uridine monophosphate synthetase
    see all

  • Pathway

    Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.
    Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

  • Involvement in disease

    Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:258900]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.

  • Sequence similarities

    In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
    In the C-terminal section; belongs to the OMP decarboxylase family.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant OPRT protein (Tagged) (ab240863)
    SDS-PAGE - Recombinant OPRT protein (Tagged) (ab240863)

    (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel of ab240863.

References

ab240863 has not yet been referenced specifically in any publications.

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