Product nameRecombinant p17 Treponema pallidum protein
Biological activityReacts strongly with human T. pallidum positive serum.
Purity> 95 % SDS-PAGE.
Expression systemEscherichia coli
Protein lengthFull length protein
Our Abpromise guarantee covers the use of ab49009 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesReacts strongly with human T. pallidum positive serum.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Constituents: 48% Urea, 0.078% Beta mercaptoethanol, 0.316% Tris HCl
- tpp17 protein
- Treponema Pallidum Lipoprotein p17
Relevancep17 is a 17-kDa major membrane lipoprotein of Treponema pallidum. The complete genome sequence of Treponema pallidum has been determined and shown to be 1,138,006 base pairs containing 1041 predicted coding sequences (open reading frames). Systems for DNA replication, transcription, translation, and repair are intact, but catabolic and biosynthetic activities are minimized. Treponema pallidum is a gram-negative spirochaete bacterium and there are at least four known subspecies: T. pallidum pallidum, which causes syphilis; T. pallidum pertenue, which causes yaws; T. pallidum carateum, which causes pinta; and T. pallidum endemicum, which causes bejel. There is no vaccine for syphilis. The outer membrane of T. pallidum has too few surface proteins for an antibody to be effective. Efforts to develop a safe and effective syphilis vaccine have been hindered by uncertainty about the relative importance of humoral and cellular mechanisms to protective immunity and the fact that T. pallidum outer membrane proteins have not been unambiguously identified.
Cellular localizationBacterial cell membrane; lipid-anchor (Probable).
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab49009 has not yet been referenced specifically in any publications.