Recombinant Rabbit CD86 protein (His tag) (ab215594)

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Description

  • Product name

    Recombinant Rabbit CD86 protein (His tag)
    See all CD86 proteins and peptides

  • Purity

    > 95 % SDS-PAGE.

  • Endotoxin level

    < 1.000 Eu/µg

  • Expression system

    Mammalian

  • Accession

    P42071

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Rabbit

    • Sequence

      AASLRIQAYFNKTADLPCQFTNSQSRSLSELVVFWQDQERLVLYELFLGR EKPDNVDPKYIGRTSFDQESWNLQLHNVQIKDKGVYQCFVHHRGAKGLVP IYQMNSELSVLANFTQPEITLISNITRNSAINLTCSSVQGYPEPKKMFFV LKTENATTEYDGVIEKSQDNVTGLYNISISGSITFSDDIRNATIYCVLQT ESTETYSQHFPIVPADPVPVEKPRHHHHHH

    • Predicted molecular weight

      26 kDa including tags

    • Amino acids

      23 to 246

    • Tags

      His tag C-Terminus

Specifications

Our Abpromise guarantee covers the use of ab215594 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C long term.

    pH: 7.40
    Constituent: 100% PBS

    Lyophilized from a 0.2 µm filtered solution

  • Reconstitution
    Reconstitute with ddH2O to a concentration no less than 100 µg/mL. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

General Info

  • Alternative names

    • Activation B7-2 antigen
    • Activation B7-2 antigen 3
    • B-lymphocyte activation antigen B7-2
    • B-lymphocyte activation antigen B7-2 2
    • B7
    • B7 2
    • B7-2
    • B7.2
    • B70
    • B72
    • B72 antigen
    • BU63
    • CD28 antigen ligand 2
    • CD28 antigen ligand 2 2
    • Cd28l2
    • CD28LG2
    • CD86
    • CD86 antigen
    • CD86 antigen (CD28 antigen ligand 2 B7 2 antigen)
    • CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)
    • CD86 antigen (CD28 antigen ligand 2, B7-2 antigen) 1, 2
    • CD86 molecule
    • CD86_HUMAN
    • CLS1
    • CTLA-4 counter-receptor B7.2
    • CTLA-4 counter-receptor B7.2 2
    • CTLA-4 counter-receptor B7.2 2, 3
    • Early T-cell costimulatory molecule 1
    • ETC-1
    • FUN 1
    • FUN-1
    • FUN1
    • LAB72
    • Ly-58
    • Ly58
    • MB7
    • MB7-2
    • Membrane glycoprotein
    • MGC34413
    • T lymphocyte activation antigen CD86 precursor
    • T-lymphocyte activation antigen CD86
    • TS/A-2
    see all

  • Function

    Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.

  • Tissue specificity

    Expressed by activated B-lymphocytes and monocytes.

  • Sequence similarities

    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.

  • Post-translational
    modifications

    Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.

  • Cellular localization

    Membrane.
  • Information by UniProt

References

ab215594 has not yet been referenced specifically in any publications.

Publishing research using ab215594? Please let us know so that we can cite the reference in this datasheet.

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