The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
The biological activity of recombinant rabbit IL-2 measured in a cell proliferation assay using CTLL2 mouse cytotoxic T cells. The ED50 for this effect is typically 9.5 – 14.0 ng/mL.
% SDS-PAGE. Ion-exchange chromatography
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Constituents: 2.68% PBS, 10% Trehalose
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein. Stable for up to twelve months from date of receipt at -20°C. Once reconstituted stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.
Involved in regulation of T cell clonal expansion
T Cell Growth Factor
T-cell growth factor
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
Involvement in disease
Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.