Recombinant Rat Factor I/CFI protein (Tagged) (ab267985)
Key features and details
- Expression system: Mammalian
- Purity: > 85% SDS-PAGE
- Tags: Myc tag C-Terminus, 10x HIS tag N-Terminus
- Suitable for: SDS-PAGE
Description
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Product name
Recombinant Rat Factor I/CFI protein (Tagged) -
Purity
> 85 % SDS-PAGE. -
Expression system
Mammalian -
Accession
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Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Rat -
Sequence
KNTPASGQPQEDLVEQKCLLKNYTHHSCDKVFCQPWQKCIEGTCACKLPY QCPKAGTPVCATNGRGYPTYCHLKSFECLHPEIKFSNNGTCTAEEKFNVS LIYGSTDTEGIVQVKLVDQDEKMFICKNSWSTVEANVACFDLGFPLGVRD IQGRFNIPVNHKINSTECLHVRCQGVETSLAECTFTKKSSKAPHGLAGVV CYTQDADFPTSQSFQCVNGKRIPQEKACDGVNDCGDQSDELCCKGCRGQA FLCKSGVCIPNQRKCNGEVDCITGEDESGCEEDKKNKIHKGLARSDQGGE TEIETEETEMLTPDMDTERKRIKSLLPKLSCGVKRNTHIRRKRVVGGKPA EMGDYPWQVAIKDGDRITCGGIYIGGCWILTAAHCVRPSRYRNYQVWTSL LDWLKPNSQLAVQGVSRVVVHEKYNGATYQNDIALVEMKKHPGKKECELI NSVPACVPWSPYLFQPNDRCIISGWGREKDNQKVYSLRWGEVDLIGNCSR FYPGRYYEKEMQCAGTSDGSIDACKGDSGGPLVCKDVNNVTYVWGIVSWG ENCGKPEFPGVYTRVASYFDWISYYVGRPLVSQYNV -
Predicted molecular weight
66 kDa -
Amino acids
19 to 604 -
Tags
Myc tag C-Terminus , 10x HIS tag N-Terminus -
Additional sequence information
Mature chain N-terminal 10xHis-tagged and C-terminal Myc-tagged
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab267985 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
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Form
Liquid -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 8.00
Constituents: 50% Glycerol (glycerin, glycerine), 50% Tris buffer
General Info
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Alternative names
- AHUS3
- ARMD13
- C3b INA
see all -
Function
Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively. -
Tissue specificity
Plasma. -
Involvement in disease
Defects in CFI are a cause of susceptibility to hemolytic uremic syndrome atypical type 3 (AHUS3) [MIM:612923]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.
Defects in CFI are the cause of complement factor I deficiency (CFI deficiency) [MIM:610984]. CFI deficiency is an autosomal recessive condition associated with a propensity to pyogenic infections. -
Sequence similarities
Belongs to the peptidase S1 family.
Contains 1 Kazal-like domain.
Contains 2 LDL-receptor class A domains.
Contains 1 peptidase S1 domain.
Contains 1 SRCR domain. -
Cellular localization
Secreted > extracellular space. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab267985 has not yet been referenced specifically in any publications.