Recombinant rat FGF1 alpha protein (ab129142)

Description

  • Product name

    Recombinant rat FGF1 alpha protein
    See all FGF1 alpha proteins and peptides
  • Biological activity

    Determined by a cell proliferation assay using balb/c 3T3 cells. The expected ED50 is = 0.1 ng/ml, in the presence of 10 µg/ml heparin, corresponding to a specific activity of = 1 x 107 units/mg.
  • Purity

    > 95 % SDS-PAGE.
    Purity: > 95% by SDS-PAGE and HPLC analysis.
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Rat
    • Sequence

      MFNLPLGNYK KPKLLYCSNG GHFLRILPDG TVDGTRDRSD QHIQLQLSAE SAGEVYIKGT ETGQYLAMDT EGLLYGSQTP NEECLFLERL EENHYNTYTS KKHAEKNWFV GLKKNGSCKR GPRTHYGQKA ILFLPLPVSS D
    • Predicted molecular weight

      16 kDa
    • Amino acids

      16 to 155

Specifications

Our Abpromise guarantee covers the use of ab129142 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

    SDS-PAGE

    HPLC

  • Form

    Lyophilised
  • Additional notes

    Endotoxin level: < 0.1 ng/µg.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. The lyophilized protein is stable for a few weeks at room temperature. Store at -20°C long term.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    Reconstituted ab129142 should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles.

General Info

  • Alternative names

    • Acidic fibroblast growth factor
    • aFGF
    • Beta-endothelial cell growth factor
    • ECGF-beta
    • Endothelial cell growth factor
    • Fgf1
    • FGF1_HUMAN
    • HBGF-1
    • Heparin-binding growth factor 1
    see all
  • Function

    The heparin-binding fibroblast growth factors play important roles in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. They are potent mitogens in vitro.
  • Sequence similarities

    Belongs to the heparin-binding growth factors family.
  • Cellular localization

    Secreted. Cytoplasm. Cytoplasm > cell cortex. Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1.
  • Information by UniProt

References

ab129142 has not yet been referenced specifically in any publications.

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