Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Guanine nucleotide-binding protein G(t) subunit alpha-3
Gustducin alpha-3 chain
Transducin beta chain 1
GNAT3 is a transducin-like heterotrimeric guanine nucleotide-binding protein (G-protein) expressed in taste receptor cells (TRCs) of the tongue. It is also expressed in the stomach and intestine in brush cells that are scattered throughout the surface epithelium of the gut and share
structural features of taste receptor cells of the tongue. GNAT3 was demonstrated to be myristolated and was also palmitoylated in insect cells.
Biochemical and genetic studies have implicated
GNAT3 as a key component in the transduction of both bitter and sweet taste. GNAT3 mediates two responses, i.e. a decrease in cyclic nucleotide monophosphates via activation of phosphodiesterase 1A by GNAT3-alpha and activation of phospholipase C-beta by released G-beta-gamma subunits.
has not yet been referenced specifically in any publications.
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