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  1. Link

    recombinant-rat-igf1-protein-ab52006.pdf

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Signal Transduction Growth Factors/Hormones Insulin / Insulin-like
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Recombinant Rat IGF1 protein (ab52006)

  • Datasheet
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Key features and details

  • Expression system: Escherichia coli
  • Purity: > 95% SDS-PAGE
  • Suitable for: Functional Studies, SDS-PAGE

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Description

  • Product name

    Recombinant Rat IGF1 protein
    See all IGF1 proteins and peptides
  • Purity

    > 95 % SDS-PAGE.
    Greater than 95% by SDS-PAGE and HPLC analyses.
  • Expression system

    Escherichia coli
  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Rat

Associated products

    Specifications

    Our Abpromise guarantee covers the use of ab52006 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Functional Studies

      SDS-PAGE

    • Form

      Lyophilized
    • Additional notes

      This solution can be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use. The lyophilized IGF-I is best-stored desiccated below 0°C. Reconstituted IGF-I should be stored at working aliquots at -20°C.
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

      Preservative: None
      Endotoxin level is <0.1 ng per µg of IGF-I.

    • Reconstitution
      Reconstitute in water to a concentration of 0.1-1.0 mg/ml.

    General Info

    • Alternative names

      • IBP1
      • IGF I
      • IGF IA
      • IGF IB
      • IGF-I
      • Igf1
      • IGF1_HUMAN
      • IGF1A
      • IGFI
      • IGFIA
      • Insulin like growth factor 1
      • Insulin like growth factor 1 (somatomedin C)
      • Insulin like growth factor IA
      • Insulin like growth factor IB
      • Insulin-like growth factor I
      • Mechano growth factor
      • MGF
      • OTTHUMP00000195080
      • OTTHUMP00000195081
      • OTTHUMP00000195082
      • OTTHUMP00000195083
      • OTTHUMP00000195084
      • Somatomedia C
      • Somatomedin C
      • Somatomedin-C
      see all
    • Function

      The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.
    • Involvement in disease

      Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
    • Sequence similarities

      Belongs to the insulin family.
    • Cellular localization

      Secreted.
    • Target information above from: UniProt accession P05019 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (2)

    Publishing research using ab52006? Please let us know so that we can cite the reference in this datasheet.

    ab52006 has been referenced in 2 publications.

    • Chen H  et al. Prolyl hydroxylase 2 silencing enhances the paracrine effects of mesenchymal stem cells on necrotizing enterocolitis in an NF-?B-dependent mechanism. Cell Death Dis 11:188 (2020). PubMed: 32179740
    • Yang X  et al. IGF-1 protects retinal ganglion cells from hypoxia-induced apoptosis by activating the Erk-1/2 and Akt pathways. Mol Vis 19:1901-12 (2013). PubMed: 24049436

    Customer reviews and Q&As

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    Please use the links above to contact us or submit feedback about this product.

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