Recombinant Rat IGF1 protein (ab52006)
- Datasheet
- References (1)
- Protocols
Description
-
Product name
Recombinant Rat IGF1 protein
See all IGF1 proteins and peptides -
Purity
> 95 % SDS-PAGE.
Greater than 95% by SDS-PAGE and HPLC analyses. -
Expression system
Escherichia coli -
Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
-
Species
Rat
-
Specifications
Our Abpromise guarantee covers the use of ab52006 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
-
Applications
Functional Studies
SDS-PAGE
-
Form
Lyophilised -
Additional notes
This solution can be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use. The lyophilized IGF-I is best-stored desiccated below 0°C. Reconstituted IGF-I should be stored at working aliquots at -20°C. -
Concentration information loading...
Preparation and Storage
-
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Preservative: None
Endotoxin level is <0.1 ng per µg of IGF-I. -
ReconstitutionReconstitute in water to a concentration of 0.1-1.0 mg/ml.
General Info
-
Alternative names
- IBP1
- IGF I
- IGF IA
see all -
Function
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. -
Involvement in disease
Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation. -
Sequence similarities
Belongs to the insulin family. -
Cellular localization
Secreted. - Information by UniProt
Datasheets and documents
References
This product has been referenced in:
- Yang X et al. IGF-1 protects retinal ganglion cells from hypoxia-induced apoptosis by activating the Erk-1/2 and Akt pathways. Mol Vis 19:1901-12 (2013). Read more (PubMed: 24049436) »
