Description

  • Product name

    Recombinant Rat PLGF protein
    See all PLGF proteins and peptides
  • Purity

    > 95 % SDS-PAGE.
    The purity of ab190989 is greater than 95% by SDS-PAGE gel and HPLC analyses.
  • Endotoxin level

    < 0.100 Eu/µg
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Rat
    • Sequence

      ALSAGNNSTE MEVVPFNEVW GRSYCRPMEK LVYIADEHPN EVSHIFSPSC VLLSRCSGCC GDEGLHCVAL KTANITMQIL KIPPNRDPHS YVEMTFSQDV LCECRPILET TKAERRKTKG KRKQSKTPQT EEPHL
    • Predicted molecular weight

      30 kDa
    • Amino acids

      24 to 158
    • Additional sequence information

      ab190989 is the mature full length protein from aa 24 to 158. The signal peptide is not included. ab190989 is a 30.3 kDa disulfide-linked homodimeric protein of two 135 amino acid polypeptide chains.

Specifications

Our Abpromise guarantee covers the use of ab190989 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    HPLC

  • Form

    Lyophilised
  • Additional notes

    Avoid inhalation. Avoid contact with eyes, skin and clothing.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C.

  • Reconstitution
    For lot specific reconstitution information please contact our Scientific Support Team.

General Info

  • Alternative names

    • D12S1900
    • Pgf
    • PGFL
    • PIGF
    • Placenta growth factor
    • Placental growth factor
    • Placental growth factor, vascular endothelial growth factor related protein
    • PlGF
    • PlGF 2
    • PLGF_HUMAN
    • PlGF2
    • SHGC 10760
    see all
  • Function

    Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner.
  • Tissue specificity

    While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas.
  • Sequence similarities

    Belongs to the PDGF/VEGF growth factor family.
  • Domain

    Isoform PlGF-2 contains a basic insert which acts as a cell retention signal.
  • Post-translational
    modifications

    N-glycosylated.
  • Cellular localization

    Secreted. The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.
  • Information by UniProt

References

ab190989 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab190989.
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