Description

  • Product name

    Recombinant rat RAB1B protein
  • Biological activity

    Activity: 100 pmol of protein can bind > 80 pmol of GDP.
  • Purity

    > 90 % SDS-PAGE.

  • Expression system

    Escherichia coli
  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Rat

Specifications

Our Abpromise guarantee covers the use of ab90789 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.00044% GDP, 0.019% Magnesium chloride, 0.0156% Beta mercaptoethanol, 0.79% Tris HCl, 1.16% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • RAB1B
    • RAB1B member RAS oncogene family
    • RAB1B_HUMAN
    • Ras related protein Rab1B
    • Ras-related protein Rab-1B
    • Small GTP binding protein
    see all
  • Function

    Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments.
  • Sequence similarities

    Belongs to the small GTPase superfamily. Rab family.
  • Post-translational
    modifications

    Prenylated; by GGTase II, only after interaction of the substrate with Rab escort protein 1 (REP1).
    AMPylation at Tyr-77 occurs in the switch 2 region and leads to moderate inactivation of the GTPase activity. It appears to prolong the lifetime of the GTP state of RAB1B by restricting access of GTPase effectors to switch 2 and blocking effector-stimulated GTP hydrolysis, thereby rendering RAB1B constitutively active.
  • Cellular localization

    Membrane. Cytoplasm. Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles between these two compartments. In the GDP-form, colocalizes with GDI in the cytoplasm.
  • Information by UniProt

References

ab90789 has not yet been referenced specifically in any publications.

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